1、PSEUDORABIESControl and Eradication伪狂犬病的控制和清除朱稳森美国谷物协会 广州Pseudorabies 伪狂犬病PRV 伪狂犬病病毒Aujeskys Disease (AD) 奥叶斯基病Infectious Bulbar Paralysis感染性延髓麻痹Historical Records report disease in Cattle in early 1800s早在1800年有报道该病发生于牛All species of mammals susceptible. 哺乳动物易感Cats, Dogs, Sheep, Cattle, Horses, Rats
2、, Monkeys.Man is resistant. Rare reports in Humans (Skin rash).人有抵抗性，人感染的报道很少见（皮疹）PRV was often confused with swine fever.常与猪瘟相混急性：流产，木乃伊，死胎，不孕腹泻，中枢神经症状High mortality in small pigs 仔猪高死亡率Pre-wean can be almost 100% 断奶前几乎1005 - 9 weeks less than 10% 59周龄低于10Less than 2% in older pigs 稍大猪低于2Coughing,
3、sneezing 咳嗽，喷嚏Skin lesions/Itching (not common) 皮肤病变/痒（不多见）Varying pathogenicity, sometimes acute form not seen病毒的致病性不同，有时未见急性型慢性：Pneumonia in Grow-finish 生长肥育阶段肺炎Immunity from sow lasts forup to 15 weeks, protective 6 to 12 weeks母体免疫力 15 周龄， 性 612 周龄Immunosuppression, Secondary Infection 免疫 制， 发感染A
4、PP, Strep, Mycoplasma InteractionsSow herd fairly stable, G/F is virus factory母猪 很稳 ，生长肥育猪产生病毒Immunity can be cyclic in sow herd 母猪 免疫力 Pseudorabies Spread 伪狂犬病的 Infected Pigs - 病猪Lifetime Latent infection 感染Virus Shedding when stressed状 产生病毒Fomites 染物Trucks, Boots, Premises， ， Aerosol Spreads 3 km
5、very easily很 易 3 Circle/Area Vaccination Essential/免疫currency1的PRV - Route of Infection 感染“Intranasal/oral route/“Nasal Epithelial cells fi皮fl Nerve Cells - - - up nerves to CNS神经fl fi中枢神经Tonsil 体Respiratory Tract道Lymphoid Tissues ”Semen/Uterine route possible的 / “After Infection: 感染 The Pig sheds v
6、irus for 10 to 14 days.1014产生病毒Virus becomes Latent in Nerve Tissue.病毒在神经 Pig is infected for its Lifetime.生感染Periodic recrudescence occurs.周性发Latent Infection is detectable by PCR.PCR 感染Gross Lesions 体病变Sometimes No Gross Lesions are visible有时见不 体病变Multiple White Foci on Liver & Spleen 和 多病 Intrana
7、sal/tonsillar Necrosis (not common)/ 体 死（不常见）Pulmonary Edema肺 Pneumonia肺炎Facial Skin Lesions are rare.皮肤病变少见Microscopic Lesions 病变Meningitis 炎Encephalitis （大） 炎Perivascular Cuffing 周 Bronchitis 炎Interstitial Pneumonia 性肺炎Necrotic Foci in Liver & Spleen 和 的 死性病 Enteric Lesions 道病变Differential Diagnosis 断Swine Influenza 猪流感Parvovirus fl 病毒Circoviral “Shaker Pig Disease”状病毒性猪 病Classical Swine Fever 经型猪瘟PRRS 病Enterovirus 病毒
