化疗药物配制指南.doc

1、化疗药配备Common Antineoplastic Drug Pharmacy Preparation Chart Generic Name(INN)Trade Name Concentration /DiluentPrecautions /Stock SolutionStabilityVehicle forInfusionPrecautions /Ready-to-UseSolutionStabilityAmifostine Ethyol 500 mg in 9.7mL of 0.9% NaCl6 hrs (RT)24 hrs(refrigerated)n.r. Administerwit

2、hin 25 minutesAsparaginase Asparaginase 10,000 U in 4mL of WFIIn the dark,6 hrs)5% Dex / 0.9% NaClAzathioprine Imurek 50 mg in 5-15mL of WFI120 hrs (RTor refrigerated)0.9% NaCl or 0.18% NaCl + 4% DexAdminister after preparationBleomycin Bleomycin Numerous incompatibilities0.9% NaClCarboplatin Carbop

3、lat 50 mg in 5 mL In the dark 5% Dex / 0.9% NaCl Conc 0.5 mg/mL8 hrs (RT) 24 hrs (refrigerated)Carmustine(BCNU)Carmubris Dissolve in 3 mL of ethanol, add 27 mL of WFI100 mg in 30 mL5% Dex / 0.9% NaCl0.9% NaCl8 hrs (RT)24 hrs (refrigerated)Cisplatin Platinex 50 mg in 100 mLIn the dark, RT 0.9% NaCl8

4、hrs (RT)Cladribine Leustatin 10 mg in 10 mL 0.9% NaClAdminister within 0.1 mg/mLAdminister after preparationFilgrastim(G-CSF)Neupogen 300 g in 1 mL Refrigerated 5% Dex. NO NaCl Conc 24 hrs (refrigerated)2 g/mLFludarabine Fludara 50 mg in 2 mL of WFI8 hrs 5% Dex / 0.9% NaClFluorouracil(5-FU)Fluroblas

5、tin 1,000 mg in 20 mLIn the dark, RT 5% Dex Folinic AcidCalcium SaltPentahydrateLeucovorin 200 mg in 20 mLIn the dark 0.9% NaClGemcitabine Gemzar 200 mg in 5 mL of NaCl24 hrs (RT);DO NOT REFRIGERATE0.9% NaClAdminister within 30 minIdarubicin Zavedos 10 mg in 10 mL of WFI24 hrs (refrigerated)N/A, bol

6、usInject within 10-15 minIfosfamide Holoxan 1,000 mg in 25 mL of WFI48 hrs (refrigerated)5% Dex / 0.9% NaClInterferonalfa-2aRoferon A 3,000,000 U in 1 mLIn the dark, refrigeratedN/A SC or IMInterleukin-2 Proleukin Dissolve in 1.2 mL of WFI18,000,000 U in 1 mL24 hrs 5% Dex + 0.1% HAAdminister after p

7、reparationm-AMSA Amsidyl 1.5 mL of concentrate in 13.5 mL of soln (glass syringe) 75 mg in 15 mLIn the dark, 8 hrs5% Dex NO NaCl!Administer within 60-90 minMelphalan Alkeran 50 mg in 10 mL of solution / diluentIn the dark, RT; prepare immediate-ly before use0.9% NaCl. No Dex!Administer within 90 min

8、Methotrexate Methotrexate 50 mg in 2 mL In the dark 5% Dex / 0.9% NaClMitomycin C Mitomycin 10 mg in 10 mL of WFIIn the dark; prepare 5% Dex / 0.9% 3 hrs in 5% Deximmediately before useNaClMitoxantrone Novantrone,Onkotrone20 mg in 10 mL 7 days once opened5% Dex / 0.9% NaCl48 hrsNimustine ACNU 50 mg

9、in 10 mL of WFIPrepare immediately before useN/A Inject IV after preparationPaclitaxel Taxol 30 mg in 5 mL In the dark, RT 5% Dex / 0.9% NaCl Conc 0.3-1.2 mg/mL27 hrs (RT);DO NOT REFRIGERATE!USE PVC-FREE GIVING SETS!Pentostatin Nipent 10 mg in 5 mL of WFI8 hrs (RT) n.r. Administer IV or diluted with

10、in 20-30 minTeniposide VM 26 50 mg in 5 mL In the dark 5% Dex / 0.9% NaCl Conc 0.1 mg/mL24 hrs (RT);O NOT REFRIGERATE!USE PVC-FREE GIVING SETS!Thiotepa Thiotepa 15 mg in 1.5 mL of WFIRefrigerate; prepare immediately before use5% Dex / 0.9% NaClTopotecan Hycamtin 4 mg in 4 mL of WFI12 hrs (RT),24 hrs

11、 (refrigerated)5% Dex / 0.9% NaCl Conc 25-50 g/mLTreosulfan Ovastat 1,000 mg in 20 mL of WFI8 hrs n.r. Vinblastine Velbe 10 mg in 10 mL of NaClPrepare immediately before useN/A Inject IV within 1 minVincristine Vincristine 1 mg in 1 mL In the dark, 14 5% Dex days (refrigerated)/ 0.9% NaClVindesine E

12、ldisine 5 mg in 5 mL 30 days(refrigerated)N/A Inject IVVinorelbine Navelbine 10 mg in 1 mL of WFI5% Dex / 0.9% NaClAdminister within 6-10 min / 24 hrs (RT)Abbreviations: WFI = Water for Injection; HA = Human Albumin; RT = Room Temperature; 5% Dex = 5% Dextrose Injection;0.9% NaCl = 0.9% Sodium Chloride Injection Source: Deutsche Fachinformationen, BPI Service GmbH, 98/3