TheGrowingImportanceofPatinformatics.ppt

1、,SciFinder Web 新平台，新内容，新功能,SciFinder Web使用介绍,祁晶晶SciFinder 培训专员Mail：A,提纲,介绍SciFinder Web中的内容SciFinder Web的注册和登陆SciFinder Web中的检索和后处理SciFinder Web中的文献检索SciFinder Web中的物质检索SciFinder Web使用常见问题和网络资源,2,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights

2、 reserved.,美国化学文摘社Chemical Abstract Service,3,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,创建于1907年ACS的分支机构密切关注，索引和提炼着全球化学相关的文献和专利最早创立了化学文摘总部坐落于俄亥俄州的哥伦布市,SciFinder Web中的内容,4,CAS is a division of the American Chemical Society. Copy

3、right 2011 American Chemical Society. All rights reserved.,期刊,专利,论文,会议报告,溶剂，催化剂，产率,反应实验过程等,物质,基因,合成信息,SciFinder Web中的内容,5,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,提纲,介绍SciFinder Web中的内容SciFinder Web的注册和登陆SciFinder Web中的检索和后处理S

4、ciFinder Web中的文献检索SciFinder Web中的物质检索SciFinder Web使用常见问题和网络资源,6,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,SciFinder Web的系统要求,7,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All ri

5、ghts reserved.,Windows用户支持IE 7.x或者FireFox 2.xMac 用户支持 Firefox 和 SafariJava 安装（初次使用结构时自动安装）在图书馆相关页面上找到SciFinder Web注册用的网址,http:/ is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,点击URL创建SciFinder Web账号,9,CAS is a division of the American Ch

6、emical Society. Copyright 2011 American Chemical Society. All rights reserved.,开始创建SciFinder Web帐号,10,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,必须用扬州大学邮箱进行注册，即邮箱后缀必须为 “,设置用户名及密码注意事项,用户名：必须是唯一的，且包含 5-15 个字符。它可以只包含字母或字母组合、数字和/或以下

7、特殊字符： -（破折号）_（下划线). （句点）（表示“at”的符号）密码：必须包含 7-15 个字符，并且至少包含三个以下字符： 字母混合的大小写字母 数字非字母数字的字符（例如 、#、%、&、*）,11,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,密码设置小技巧：1：不要和账号中有重复的字符2：密码格式最好是abc123,对新ID的Email确认,12,CAS is a division of the Am

8、erican Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,需要点击邮件中的确认链接,Http:/scifinder.cas.org,Http:/origin-scifinder.cas.org,SciFinder Web登陆界面,13,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,输入SciFin

9、der帐号和密码,SciFinder Web登陆后主界面,14,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,文献，物质，反应检索入口，默认开始检索文献,可用的检索方法,保存过的结果集,邮件提醒结果集,检索完，请点击退出,提纲,介绍SciFinder Web中的内容SciFinder Web的注册和登陆SciFinder Web中的检索和后处理SciFinder Web中的文献检索SciFinder Web中的物

10、质检索SciFinder Web使用常见问题和网络资源,15,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,课题研究中各个阶段的信息需求,16,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,课题总结：期刊、专利、会议报告。,问题？选

11、题：现有的研究条件、背景、能力。,课题申报、开题论证：国内外研究前景。,实验：实验方法，活性评价方法。,信息检索、分析、精选。,Scifinder 文献检索,2012.5.17日本研究人员在最新一期美国植物细胞杂志网络版上报告说，他们通过让水稻体内一个“Nramp5”的基因不发挥作用，培育出了几乎不吸收有毒的重金属镉的水稻；农田土壤环境日益恶化（“三废”排放，污水、垃圾、含有重金属的农药及化肥），水稻中重金属含量较高；新课题“水稻镉污染及其对镉的吸收、代谢机制”,17,CAS is a division of the American Chemical Society. Copyright 2

12、011 American Chemical Society. All rights reserved.,Scifinder web-文献检索,案例：水稻镉污染及其对镉的吸收、代谢机制,18,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,确定主题词：水稻（rice， paddy rice ） 镉污染（ cadmium pollution、 Cadmium contamination）,文献类型：综述、最新期刊、专利

13、,明确检索需求：确定学科范围（生物类、分析化学、合成），方向（制备、工艺、晶体结构、副作用、临床）,同义词、单复数、不同时态,Scifinder web文献检索,水稻镉污染,19,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,提前限制出版年限、文献类型、语言等,主题词之间用（of, with, in )等介词连接,主题检索候选项,20,CAS is a division of the American Chemi

14、cal Society. Copyright 2011 American Chemical Society. All rights reserved.,各选项含义：“as antered” 表示完全匹配“Concepts”表示对主题词做了同义词的扩展“Closely associated with one another”表示同时出现在一个句子中“were present anywhere in the reference”表示同时出现在一篇文献中,Scifinder web文献检索结果,21,CAS is a division of the American Chemical Society

15、. Copyright 2011 American Chemical Society. All rights reserved.,全文链接,文献分析和限定工具,物质及被引用的文献链接,文献排序工具,工具栏,Sort by 文献结果的排序功能,22,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,4种排序方式，可以按照登陆号、作者名、引文排序、出版年限、标题对文献检索结果进行重新排序,Citing Reference

16、s 引文排序,23,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,快速获得被引用次数最多的文献，查看具有参考价值的文献,获得施引文献,Get citing 获得施引文献,24,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,帮助研究者

17、快速了解这个主题的最新研究情况及应用领域,外源性NO受体保护青蒿免受硼、铝的毒性产生的氧化应激作用植物中重金属毒性及耐受性的机制研究,吸收,Analysis 文献的分析工具,25,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,历史导航条，返回原先的检索界面,12种分析方法，帮助筛选文献,Index Term 索引词分析,26,CAS is a division of the American Chemical S

18、ociety. Copyright 2011 American Chemical Society. All rights reserved.,快速了解文献研究的主要内容以及该领域的一些标准词汇，有助于选择合适的检索词，同时可以精选文献,根叶,文献的筛选及快速查看,27,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,继续分析,Quick view快速查看,Publication Year 出版年限分析,28,CAS

19、 is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,Natural Order出版年限排序,了解该领域的研究历史和发展,29,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,组织机构分析：了解潜在的竞争者、合作伙伴,作者分析：发现本领域、课题的主

20、要研究人员，以及同行评审专家,来源期刊分析：发现相关的学术期刊，快速定位投稿期刊,Refine 文献的限定工具,30,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,六种限定工具，包括主题词、作者姓名、机构名称、出版年代、语言、所属数据库,文献类型,专利,限定专利类文献,31,CAS is a division of the American Chemical Society. Copyright 2011 Ame

21、rican Chemical Society. All rights reserved.,了解专利的状态,快速筛选不同学科的相关文献,Categorize 系统分类功能,32,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,Categorize系统分类功能,33,CAS is a division of the American Chemical Society. Copyright 2011 American C

22、hemical Society. All rights reserved.,一级目录,二级目录,和二级目录有关的Index Term,Categorize 筛选分析化学相关的文献,34,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,分析方法：原子吸收分光光度法红外光谱质谱,点击标题查看文献的详细内容,35,CAS is a division of the American Chemical Society. Co

23、pyright 2011 American Chemical Society. All rights reserved.,36,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,CAS编写过的摘要信息,重要概念索引,物质信息,文献结果保存,37,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical So

24、ciety. All rights reserved.,Save保存到远程电脑上Export保存到本地电脑上,Citation manager: 保存成RIS格式，用于导入EndNote等文献管理工具Offline Review:保存过成PDF，RTF格式，用于脱机浏览,文献检索小结,主题检索时，使用介词作为连接尽量选择包含Concept和Closed Associated with的候选项通过SciFinder 的Analyze/Refine功能来缩小检索的范围尝试将不同的Analyze/Refine功能组合起来用，会有更多的收益使用Categorize可以让系统来实现自动分类更多细节化内容

25、，请参考 is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,提纲,介绍SciFinder Web中的内容SciFinder Web的注册和登陆SciFinder Web中的检索和后处理SciFinder Web中的文献检索SciFinder Web中的物质检索SciFinder Web使用常见问题和网络资源,39,CAS is a division of the American Chemical Society. Copy

26、right 2011 American Chemical Society. All rights reserved.,Scifinder web 物质检索,40,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,化学结构检索Markush检索分子式检索性质检索物质标示符检索,双击打开绘图面板,不同的检索需求，采用的检索方法不一样,案例1: 3-羟基丙酸,3-羟基丙酸（503-66-2；propionic acid 3

27、-hydroxy），光学活性物质的前体；可以作为生产1，3一丙二醇(PDO)、丁二酸，特种聚酯和丙烯酸的原料；化学工艺的角度出发的，具有能耗高、污染大、副产物多、分离困难等缺点查找3-hp的理化性质、图谱、寻找经济又环保的合成方法,41,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,Substance Identifier 物质标示符检索,42,CAS is a division of the American

28、Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,可以输入物质的名称，CA号，俗名，商品名，来进行检索,查找3-羟基丙酸（503-66-2）的理化性质,物质检索结果,43,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,物质的图谱物质的实验性质,物质的参考文献物质的反应信息物质的商品信息物质的管控信息,点

29、击查看物质的详细信息,物质的详细信息,44,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,物质及其衍生物在不同角色下的专利、非专利文献分类,获得物质在生物学中的专利文献,物质的预测及实验性质,45,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights rese

30、rved.,熔沸点、密度、LD50、H键供受体、logP。,物质的图谱信息,46,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,查找经济环保的合成方法,47,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,获得该物质合成信息,48,C

31、AS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,筛选生物转化类的反应记录,49,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,查看反应的详细记录，调研其生物转化的制备方法,报道了丙二醇利用乳酸菌PduP蛋白促使甘油发酵生产3-hp的机制

32、,50,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,SciFinder结构绘制工具,CAS号转换为化学结构,51,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,绿原酸CAS号： 327-97-9,Scifinder web 绘图面

33、板,52,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,精确结构检索亚结构检索相似结构检索,精确结构检索,53,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,单一组分,有机物,精确结构检索结果,54,CAS is a divisio

34、n of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,物质的生物活性标记,55,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,列出绿原酸参与的生物活性研究的分类及参考文献。比如：抗菌剂、抗肿瘤等。,抗肿瘤,获得138篇绿原酸参与的抗肿瘤研究方面的文献,靶点标记信息,56,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,