1、,SciFinder数据库使用培训,南京林业大学2013.04,SciFinder Web培训,SciFinder Web介绍SciFinder Web中的内容SciFinder Web特色功能SciFinder Web中的检索SciFinder Web中的常规检索举例SciFinder Web中的其他应用举例SciFinder Web的注册和常见问题,2,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,美国化学文
2、摘社Chemical Abstract Service,3,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,ACS的分支机构,创立于1907年致力于跟踪、索引并提炼全球化学相关的科技文献信息最先创立了纸本化学文摘Chemical Abstracts TM总部位于俄亥俄州的哥伦布市,1300名员工,精通50多种语言。关注索引上万种期刊和63家专利客户覆盖全球1900所高校、500强公司以及所有主要的专利局。,SciF
3、inder Web中的几个主要数据库,4,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,CAplusSM 涵盖了上万种期刊及63个专利发行机构专利,5,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,India (IN),China
4、(CN),Singapore (SG),Republic of Korea (KR),Philippines (PH),Taiwan (TW),Hong Kong (HK),Japanese Patent Office (JPO),CAplusSM中的索引词帮助解决各种描述歧义问题,文献检索过程中经常遇到很多同义词、近义词、单复数、不同时态的情况,科研人员常常花费大量的时间进行检索式的编辑;全球科研人员对同一概念的描述,受语种习惯,教育背景的不同而不同SciFinder Web中的Index term是一种标准化的索引词,配合智能化的检索模式,保证检索的全面性,6,CAS is a divis
5、ion of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,CAS REGISTRYSM 是化学物质信息的“黄金标准”,7,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,CASREACT 是检索化学反应最权威的来源,8,CAS is a division of the Am
6、erican Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,CASREACT是世界上最大的,更新速度最快的反应数据库,MARPAT 全球专利文献中的Markush结构库,9,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,MARPAT帮助最大程度的找到结构相关专利文献,SciFinder Web登陆界
7、面http:/scifinder.cas.org http:/origin-scifinder.cas.org,10,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,输入SciFinder帐号和密码,SciFinder Web登陆后主界面,11,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical S
8、ociety. All rights reserved.,文献,物质,反应检索入口,默认开始检索文献,可用的检索方法,保存过的结果集,邮件提醒结果集,检索完,请点击退出,提纲,SciFinder Web介绍SciFinder Web中的内容SciFinder Web特色功能SciFinder Web中的检索SciFinder Web中的常规检索举例SciFinder Web中的其他应用举例SciFinder Web的注册和常见问题,12,CAS is a division of the American Chemical Society. Copyright 2011 American Che
9、mical Society. All rights reserved.,SciFinder Web特色功能根据引文排序,13,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,依据被引次数排序,SciFinder Web特色功能Quick View (Reference),14,CAS is a division of the American Chemical Society. Copyright 2011 Ame
10、rican Chemical Society. All rights reserved.,快速查看文献的摘要、物质、图片信息,SciFinder Web特色功能物质的靶标和生物活性,15,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,在物质详细信息栏,可以查询到物质的生物活性信息和靶标信息,SciFinder Web特色功能依据物质性质检索,16,CAS is a division of the American
11、 Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,性质检索,可通过物质的熔沸点、分子量等实验和预测性质查看物质信息,SciFinder Web特色功能SciPlanner合成路线设计,17,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,SciFinder Web特色功能反应过程的获取,18,CAS i
12、s a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,SciFinder中的部分源自期刊和专利中的反应,提供了反应过程信息,使得科研工作者不需要阅读原文,就可以获得对应的反应历程。,提纲,SciFinder Web介绍SciFinder Web中的内容SciFinder Web特色功能SciFinder Web中的检索SciFinder Web中的常规检索举例SciFinder Web中的其他应用举例SciFinder Web的注
13、册和常见问题,19,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,Scifinder web-文献检索,案例:天然产物中的抗肿瘤物质 Natrual products of anti-tumor,20,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights re
14、served.,主题词之间用(of, with, in )等介词连接,主题检索候选项,21,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,“Concept”表示做了同义词的扩展,保证文献检索的全面性,Scifinder web文献检索结果,22,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical
15、Society. All rights reserved.,全文链接,文献分析和限定工具,物质及被引用的文献链接,工具栏,文献结果的处理,23,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,如何在大量文献中发现最关健的信息?,文献分析,12种分析方法,可以帮助我们逐步了解信息需求,Index term 索引词分析,24,CAS is a division of the American Chemical Soci
16、ety. Copyright 2011 American Chemical Society. All rights reserved.,快速了解文献研究的主要内容,精选文献,构效关系研究,Publication Year 出版年限分析,25,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,出版年:了解该领域的研究历史和发展,Natural Order出版年限排序,天然产物中抗肿瘤药物研究趋势图,26,CAS is
17、a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,组织机构分析:了解潜在的竞争者、合作伙伴,作者分析:发现本领域、课题的主要研究人员,以及同行评审专家,来源期刊分析:发现相关的学术期刊,快速定位投稿期刊,文献的限定Refine,27,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All ri
18、ghts reserved.,如何获得综述类、临床研究方面的文献?,文献限定,利用“document type”可以筛选综述、临床研究、论文、专利等特定类型的文献,获得一千多篇综述、临床研究的文献,28,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,Citing References引文索引排序,Categorize 系统分类功能,29,CAS is a division of the American Chem
19、ical Society. Copyright 2011 American Chemical Society. All rights reserved.,快速筛选不同学科的相关文献,Categorize系统分析,30,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,合成化学,纯化物质,生物碱,31,CAS is a division of the American Chemical Society. Copyrig
20、ht 2011 American Chemical Society. All rights reserved.,HPLC、提取、NMR用于文献的筛选,分析化学,分析方法,Categorize 系统分析,文献结果的查看、保存,32,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,历史导航条,返回原先的检索界面,点击标题,查看详细信息,33,CAS is a division of the American Chemi
21、cal Society. Copyright 2011 American Chemical Society. All rights reserved.,摘要信息,一键获得物质、反应、参考文献等相关信息,34,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,重要概念索引,物质信息,文献结果保存,35,CAS is a division of the American Chemical Society. Copyrig
22、ht 2011 American Chemical Society. All rights reserved.,使用Export将结果输出,Citation manager: 保存成RIS格式,用于导入EndNote等文献管理工具Offline Review:保存过成PDF,RTF格式,用于脱机浏览,文献检索小结,主题检索时,使用介词作为连接尽量选择包含Concept和Closed Associated with的候选项通过SciFinder 的Analyze/Refine功能来缩小检索的范围尝试将不同的Analyze/Refine功能组合起来用,会有更多的收益使用Categorize可以让系
23、统来实现自动分类更多细节化内容,请参考 is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,Scifinder web 物质检索,37,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,化学结构检索Markush检索分子式检索性质检索物质标示符检索,
24、双击打开绘图面板,38,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,SciFinder结构绘制工具,CAS号直接转换为化学结构,39,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,紫杉醇CAS号: 33069-62-4,40,CA
25、S is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,精确结构检索亚结构检索相似结构检索,Substance identifier 物质标示符检索,41,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,检索紫杉醇(taxol,33069-62-4
26、)的理化性质及其生物活性,可以输入物质的名称,CA号,俗名,商品名,来进行检索,物质检索结果,42,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,物质的实验性质,一键获得参考文献、反应、商品信息,物质的角色分类(CAS Role ),43,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Soc
27、iety. All rights reserved.,按照CAS Role分类的专利、非专利文献列表。对某类文献感兴趣,仅需点击交叉处的 即可方便快捷地获取。,获得73篇紫杉醇在分析化学研究中的专利文献,生物活性标记和靶点标记,44,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,列出紫杉醇生物活性研究的分类及参考文献。比如:抗病毒、抗有丝分裂、抗感染等。,利用物质中的靶点标记功能,快速了解紫杉醇在不同靶点中的研究
28、情况。,物质的合成信息,45,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,提纲,SciFinder Web介绍SciFinder Web中的内容SciFinder Web特色功能SciFinder Web中的检索SciFinder Web中的常规检索举例SciFinder Web中的其他应用举例SciFinder Web的注册和常见问题,46,CAS is a division of the American
29、Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,聚合物检索,只知道起始原料的聚合物知道结构重复单元(SRU)的聚合物,47,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,聚合物检索,只知道起始原料的聚合物检索检索策略:组分间用点分开,每个组分采用Hill排序,括号外用x表示,48,CAS is a d
30、ivision of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,(C4H6O2.C2H3Cl.C2H3F)x,聚合物检索,知道结构重复单元(SRU)的聚合物检索检索策略:采用Hill排序,括号外用n表示,49,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,(C12H22
31、N2O2)n,注意区分n 与x的区别,聚合物的结构检索,50,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,可以在绘图面板中将不同组分的结构绘制出来,系统会自动进行碎片检索。,聚合物检索,51,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserv
32、ed.,精确检索,聚合物,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,SciFinder中的反应定义工具,52,SciFinder中的反应检索,53,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,检索符合以下条件的氰基的还原反应,
33、SciFinder中的反应检索,54,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,Variable Only at the Specified Positions:精确反应检索Substructure of more complex structure:亚结构反应检索,反应检索结果,55,CAS is a division of the American Chemical Society. Copyright
34、2011 American Chemical Society. All rights reserved.,反应分析/限定工具,反应条件、参考文献,反应分析和限定工具,56,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,筛选经济、适用的催化剂,筛选较高收率的反应记录,协助进行工艺设计,反应分类,生物转化类反应,生物转化类反应记录,57,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,同位素标记显示,对位取代的苄胺在芳香胺脱氢酶的作用下反应转化率情况,Similar Reactions相似反应检索,
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