,自噬的生理学与病理生理学作用PhysiologicalandPathphysiologicalRolesofAutophagy,Proteindegradationsystem,Ubiquitin-proteasome,Autophagylysosome,1%,99%,5hours,1980,1962,2019,?,NobelPrize,Discovery,Half-life,Percentage,E1(泛素活化酶)E2(泛素结合酶)E3(泛素-蛋白连接酶),比利时科学家德迪夫,衰老的线粒体,衰老的过氧化物酶体,FunctionofautophagyHousekeepingmechanisminvolvedincytoplasmichomeostasisB.Involvedincertaintissue-specificfunctionsCellDeathImmuneResponseDevelopmentandAgingC.AutophagyinDiseaseCancerNeurodegenerativediseasesParkinson,Huntingto