多功能纳米药物及核酸载体.DOC

1、中国微米纳米技术学会纳米科学技术分会第三届年会暨 2014 全国纳米生物与医学学术会议-四川成都1多功能纳米药物及核酸载体帅心涛*中山大学化学与化学工程学院、中山医学院，邮编: 510275; 电话: 020- 84110365; 传真: 020- 84112245; E-mail: 基于高分子的药物及基因传输纳米载体是目前非常热门的研究领域。我们制备了多种用于药物和基因或 siRNA 传输的聚合物纳米载体，通过在载体结构中引入分子靶向配体例如单链抗体、叶酸等获得了对 T 细胞、肿瘤细胞等的主动靶向传输。同时，通过在纳米载体内负载核磁共振显像（MRI）试剂，可以无创伤地检测药物和基因的靶向化输

2、送效率。Figure 1. Formation of MRI-visible targeting polyplex.参考文献1. T. M. Allen, P. R. Cullis, Science, 2004, 303, 1818-1821.2. N. Nasongkla, X. Shuai, H. Ai, J. Gao, Angew. Chem. Int. Ed., 2004, 43, 6323-6327.3. G. Chen, W. Chen, X. Shuai et al, Biomaterials, 2009, 30, 1962-1970.中国微米纳米技术学会纳米科学技术分会第三届年

3、会暨 2014 全国纳米生物与医学学术会议-四川成都2Bio-inspired synthesis and self-assembly of unique functional inorganic nanostructures, nanocomposites and their applicationsShu-Hong Yu*Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at Microscale, Department of Chemistry, Univers

4、ity of Science and Technology of China, Hefei 230026, Tel.: +86-551-3603040; Fax: +86-551-3603040, China. E-mail: Development of new methodologies for synthesis and self-assembly of unique functional nanostructures and nanocomposites has been of significance to access new materials with unique funct

5、ionalities. Herein, we will report several facile synthetic protocols for one-pot controlled synthesis of several kinds of unique inorganic nanomaterials and hybrids under mild solution conditions, in which simple organic molecules, surfactant or low molecular weight polymers have been used. The hig

6、h quality nanobuilding blocks we discussed include ultrathin nanowires, nanoplates, and magnetic nanoparticles, new hybrid semiconducting nanobelts/nanowires, conducting nanocables and nanotubes, and carbon-based nanostructures. Especially, we report that periodic ordered mesostructures of hydrophil

7、ic ultrathin nanowires can be produced by Langmuir-Blodgett technique. The mesostructures of ultrathin Te nanowire films show reversibly switched photoelectric properties. In addition, a series of layered double hydroxides (LDH) micro/nano-platelets reinforced free-standing, strong, transparent, and

8、 functional layered organic-inorganic hybrid films can be fabricated based on layer-by-layer (LBL) assembly technique using series of LDH micro/nano-platelets as building blocks. These assembled structures based on bio-inspired approaches will find potential applications in different fields.Figure 1

9、. Free-standing, strong, transparent, and functional layered organic-inorganic hybrid filmsReferences1. J. W. Liu, J. H. Zhu, C. L. Zhang, H. W. Liang, S. H. Yu, J. Am. Chem. Soc. 2010, 132, 89458952.2. H. B. Yao, H. Y. Fang, Z. H. Tan, L. H. Wu, S. H. Yu, Angew. Chem. Int. Ed. 2010, 49, 2140-2145.3. M. J. Hu, Y. Lu, S. Zhang, S. R. Guo, B. Lin, M. Zhang, S. H. Yu, J. Am. Chem. Soc. 2008, 130, 11606-11607.4. H. B. Yao, M. R. Gao, S. H. Yu, Nanoscale 2010, 2, 323-334.5. M. R. Gao, W. H. Xu, H. B. Yao, S. H. Yu, Adv. Mater. 2010, 22, 1977-1981.