MembersoftheTNF(Tumornecrosisfactor)receptorsuperfamilyplaypivotalrolesinnumerousbiologicaleventsinmetazoanorganisms.Ligand-mediatedtrimerizationbycorrespondinghomo-orhetero-trimericligands,theTNFfamilyproteins,causesrecruitmentofseveralintracellularadaptors,whichactivatemultiplesignaltransductionpathways.29TNFreceptorfamilymembershavebeenidentifiedinhumans.Basedupontheircytoplasmicsequencesandsignalingproperties,theseTNFreceptorscanbeclassifiedintothreemajorgroups(Ref.1).Thefirstgroup,including
