危重病人肾上腺皮质功能不全邱海波 东南大学附属中大医院东南大学附属中大医院ICUICU东南大学医学院急诊与危重病医学教研室东南大学医学院急诊与危重病医学教研室东南大学急诊与危重病研究所东南大学急诊与危重病研究所SepsisSepsis = InfectionInfection+SIRS+SIRS细菌侵入细菌侵入临床体征临床体征Sepsis 的概念ACCP/SCCMSevere sepsisSepsis+Signs of sepsis-related organ dysfunctionSuch as n Altered lung function (hypoxemia)n Altered renal function (increased Scr)n Altered coagulation (low platelets, DIC)n Altered liver function (hyperbilirubinemia)n Altered mental statusn Altered hemodynamic status infectioninfection损伤损伤 SIRS sepsis