1、Hypertension in the Very ElderlyLisheng LIUEpidemiologyHYVET StudyThe prevalence of hypertension in elderly population for China China definition: 160/95 mmHg or under antihypertensive treatmentMen WomenJapan (1993)60-69y: 25.1% 70y+: 29.8% 60-69y: 24.9%; 70y+: 28.6 China (1992)65-74y: 26.0%; 75y+:
2、29.1% 65-74y: 28.0%; 75y+: 34.2% XH Zhang, BHLI 2009The effect of SBP on stroke mortality by age groups in Chinese elderly populations0.51.02.04.08.016.0=180SBP (mmHg)RRofstrokemortalityAge=78yAge=74-77yAge=70-73yXH Zhang, BHLI 2009Stroke mortality in Asian menfrom 1987 to 20070500100015002000250030
3、0035004000450050001986 1991 1996 2001 2006Hong Kong Japan KoreaSingapore China_rural China_urbanMortality, per100,000YearStroke mortality in Asian womenfrom 1987 to 2007Hong Kong Japan KoreaSingapore China_rural China_urban050010001500200025003000350040001986 1991 1996 2001 2006Mortality, per100,000
4、YearBlood pressure and stroke mortality in the Chinese elderly cohort (n=4814)Age groups70-73 year 74-77 year 78 yearMenNo. of participantsage follow up years Stroke mortality（）IHD mortality（）SBP (mean SD, mmHg)DBP (mean SD, mmHg)High normal BP (SBP=120-139 &DBP=80-89 mmHg)（）Hypertension (SBP 140 or
5、 DBP 90 mmHg) （）TC（mean SD，mmol/L） Stroke mortality（）IHD mortality（）1000 71.7 0.95.03.0 7.0 1.9142.426.481.813.032.054.64.511.157.01.9881 75.21.24.82.9 8.2 2.5144.226.180.813.029.756.64.221.108.22.573781.53.34.12.69.62.4144.425.379.612.527.961.54.141.199.62.4XH Zhang, BHLI 2009Blood pressure and str
6、oke mortality in the Chinese elderly cohort (n=4814)Age groups70-73 year 74-77 year 78 yearWomenNo. of participantsAge (mean1SD, year)Years of follow up (mean1SD)SBP (mean1SD, mmHg)DBP (mean1SD, mmHg)High normal BP (SBP=120-139 &DBP=80-89 mmHg,）Hypertension (SBP 140 or DBP 90 mmHg,）TC（mean SD,mmoUL）
7、Stroke mortality（）IHD mortality()76871.60.95.12.8148.227.280.313.027.162.55.211.445.11.372975.11.24.92.9151.427.981.413.221.168.54.901.326.02.669982.53.54.22.3149.527.178.913.322.666.74.521.288.62.6XH Zhang, BHLI 2009The effects of BP on the risk of stroke mortality by age gr. in the elderly (Cox pr
8、oportional hazard regression model, controlled for age and smoking, stratified by sex)Predictors Catego-ries Age= 70-73 (year) Age=74-77 (year) Age=78 (year) HR(95%CI) P value HR (95%CI) P value HR (95%CI) P value SBP (mmHg)DBP (mmHg)Pulse pressure (mmHg)=180=100=80(Reference)1.91(1.17-3.13)1.90(1.0
9、8-3.34)3.62(2.09-6.26)Reference1.52(0.88-2.64)1.79(0.94-3.42)2.31(1.19-4.48)Reference1.24(0.67-2.26)1.38(0.72-2.66)2.83(1.57-5.10)0.010.030.00010.140.080.010.500.330.0011.76(1.07-2.90)1.87(1.10-3.17)2.75(1.63-4.65)1.31(0.84-2.03)1.89(1.19-3.02)2.37(1.43-3.91)1.77(0.92-3.41)2.33(1.22-4.43)2.54(1.35-4.78)0.020.020.00020.230.010.0010.090.010.0040.92(0.56-1.51)1.13(0.67-1.93)1.87(1.11-3.17)0.90(0.58-1.38)1.45(0.92-2.33)2.00(1.17-3.39)1.15(0.66-1.99)0.74(0.39-1.99)1.50(0.88-2.53)0.750.640.020.630.130.010.630.350.14XH Zhang, BHLI 2009
