1、 ReferencesAdjei AA, Hidalgo M. Intracellular signal transduction pathway proteins as targets for cancer therapy. J Clin Oncol 2005;23:53865403.El-Sahwi K, Bellone S, Cocco E, Cargnelutti M, Casagrande F, Bellone M, et al. In vitro activity of 帕妥珠单抗 in combination with 曲妥珠单抗 in uterine serous papill
2、ary adenocarcinoma. Br J Cancer 2010;102:134143.腹泻所有级别 29 vs. 58% 28 vs. 37%3/4级 3 vs. 12% 4 vs. 9%乏力所有级别 21 vs. 24% 28 vs. 35%3/4级 4 vs. 5% 2 vs. 4%手足综合征所有级别 13 vs. 20% 22 vs. 26%3/4级 1 vs. 1% 2 vs. 1%从试验的初步结果来看，曲妥珠单抗联合不同化疗方案临床常规一线治疗HER2 阳性胃癌或胃食管结合部癌是安全、有效的。International journal of cancer发表的，中肿和上海中山医院联合做的一项研究2012/9/4治疗方案：卡培他滨1000 mg/m2 bid d1-14 q3w x 65-氟尿嘧啶 800 mg/m2/day 持续静脉注射 d1-5 q3w x 6顺铂80 mg/m2 q3w x 6曲妥珠单抗首剂 8 mg/kg 随后 6 mg/kg 维持 q3w 直至进展为止
