布南色林：强阻断D2、D3和5-HT2A受体的DSADSA：D2受体亲和力强于5-HT2A受体亲和力SDA：5-HT2A受体亲和力强于D2受体亲和力Ki (nM)RatioD2/5-HT2A分类D2D35-HT2AAtypical antipsychotics阿立哌唑Aripiprazole 0.74 1.0 8.7 0.085 DSA布南色林Blonanser in 0.14 0.49 0.81 0.17 DSA喹硫平Quetiapine 310 650 120 2.6 SDA哌罗匹隆Perospirone 1.3 4.4 0.22 5.9 SDA奥氮平Olanzapine 17 54 1.9 8.9 SD A帕利哌酮Paliperidone4.0 7.5 0.25 16 SDA利培酮Risper idone 3.3 13 0.16 21 SD A齐拉西酮Ziprasidone 9.7 7.5 0.31 31 SDA氯氮平Clozapine 150 360 3.3 45 SDAPsychiatry Clin Neurosci. 2015; 69(5):243-58.精品课件洛珊与D2
