01肺癌免疫学治疗的背景0203其他针对肺癌的免疫学治疗进展04肺癌免疫学治疗的展望CONTENTScheck-point inhibitor免疫治疗Hallmarks of Cancer维持增殖信号失去生长抑制抵抗细胞死亡复制的永生化侵袭和转移诱导血管形成六大特征促肿瘤的炎症逃避免疫摧毁基因组不稳定和突变细胞能量失常十大特征新增4个特征The hallmarks of cancer. Cell. 2000Hallmarks of cancer: the next generation.Cell. 2011Robert A. Weinberg (AFoundingMemberoftheWhiteheadInstituteforBiomedicalResearchandProfessorofBiologyattheMassachusettsInstituteofTechnology )肿瘤免疫治疗方式Activeimmunotherapy主动免疫治 疗Adoptivecelltransferimmunotherapy过继性细胞免疫治疗IL-2IFNIL-15IL-21Peptidevac