Targeted Apoptosis of Senescent Cells Restores Tissue Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and AgingHomeostasis in Response to Chemotoxicity and AgingBaar et al.,2017,Cell 169,132147 March 23,2017 2017 Elsevier Inc.1DNA损伤修复损伤修复ApoptosisApoptosisApoptosisApoptosisSenescenceSenescenceSenescenceSenescenceorn背景介绍背景介绍清除清除持续累积持续累积加速疾病、衰老加速疾病、衰老（衰老细胞）（衰老细胞）2退出细胞周期；形成持续的促炎表型衰老相关分泌表型衰老相关分泌表型（senescence-associated secretory phenotype，SASP）；影响组织微环境；
