Confidential3D Medicines Diagnostics and Drug Development精准治疗时代下的临床研究与治疗精准治疗时代下的临床研究与治疗-机会与挑战机会与挑战思路迪精准医药思路迪精准医药 熊磊熊磊Confidential什么是精准医疗?ConfidentialISEL Trial 0709Lancet 2005;366:152737Mediansurvival56mforgefitiniband51mforplacebo63monthsvs 54monthsConfidentialIPASS EGFR 变异或者更加获益ConfidentialTKI的靶向突变获益人群开启了早期的精准治疗ConfidentialEGFR 突变:常见变异和罕见变异Nature reviews.Cancer(2007)7,169-181.JAMA.2014 May 21;311(19):1998-2006.Nat Genet.2015 May;47(5):505-11.TCGA EGFR L858R和Exon19缺失突变:占据85%的变异形式EGFR其它突变位点和突变形式