第二章药物代谢动力学药物代谢动力学药物代谢动力学药物代谢动力学PharmacokineticsPharmacokinetics1Why do me need to know PK?Optimize drug therapy to obtain a predictable response!(1)Drug of choice(2)How much(3)How often(4)For how long2Definition体内药物浓体内药物浓度随时间变度随时间变化的动力学化的动力学规律规律药物体内处置药物体内处置(Disposition)吸收吸收(Absorption)分布分布(Distribution)代谢代谢(Metabolism)排泄排泄(Excretion)3Drug AdministrationDrug Concentration in Systemic CirculationDrug in Tissues of DistributionDrug Metabolism or ExcretedDrug Concentration at Site of ActionPharmacol
