体内药物分析应用体内药物分析应用1ADMEADME早期成药性评价早期成药性评价与非临床药代动力学研究与非临床药代动力学研究Productivitytrendduring2009and2010.Theclinicalrateofsuccessisdepictedaspercentagesurvivingateachclinicalphasebasedonattritionobservedduring2009and2010.Ish KhannaDrugdiscoveryinpharmaceuticalindustry:productivitychallengesandtrendsDrug Discovery Today Volume 17,Issues 19?20 2012 1088-1102http:/dx.doi.org/10.1016/j.drudis.2012.05.007High cost high failure新药发现、开发的风险新药发现、开发的风险2NDA：new drug applicationIND:investigational new drugShiftingpar
