第二章药物代谢动力学药物代谢动力学药物代谢动力学药物代谢动力学PharmacokineticsPharmacokineticsWhy do we need to know PK?Optimize drug therapy to obtain a predictable response!(1)Drug of choice(2)How much(3)How often(4)For how longDefinition体内药物浓体内药物浓度随时间变度随时间变化的动力学化的动力学规律规律机体对药物处置机体对药物处置(Disposition)吸收吸收(Absorption)分布分布(Distribution)代谢代谢(Metabolism)排泄排泄(Excretion)Drug AdministrationDrug Concentration in Systemic CirculationDrug in Tissues of DistributionDrug Metabolism or ExcretedDrug Concentration at Site of ActionPharmacolo
