子宫颈癌保留神经的根治性子宫切除术中国医学科学院 北京协和医院 妇产科吴鸣美国细胞学不正常的结果美国细胞学不正常的结果12,20012,200cancerscancers300,000 HSIL300,000 HSIL1.25 million LSIL1.25 million LSIL2-3 million ASC2-3 million ASC50-60 million women screenedNormal cervixHPV infectionHPV-related changesLow-grade SIL(atypia,CIN I)High-grade SIL(CIN II,III/CIS)Invasive cancerBishop A,et al.PATH 1995:5About 60%regresswithin 2-3 yearsCofactorshigh-risk HPV(types 16,18,etc.)About 15%progress within 3-4 years30%-70%progress within 10 years宫颈癌发病的自然病程不同年龄组HPV感
