全身炎症反应综合症 与脓毒血症（下）XXXX医院Corticus StudyMulticenter,double-blind,RCT52 ICUs,March 2002 Nov 2005(3 yrs)Pts 18 yrs with sepsis and onset of shock within the previous 72h(SBP 1 hour)Hydrocortisone or Placebo:50 mg IV q 6h x 5 days50 mg IV q 12h on days 6 to 850 mg IV q 24h on days 9 to 11 then stoppedSprung C,et al.NEJM 2008;358:111-24Corticus StudyACTH 250 g stimulation testNon-responder:9 g/dLIntended sample size:800500 patients enrolled499 analyzableSprung C,et al.NEJM 2008;358:111-24ACTH Stimula
