1、Drugs for treatment of respiratory diseasesHuifang Tang Department of pharmacologyZhejiang University, school of Research building C4222012-3-28Antiasthmatic drugsBronchial asthma： inflammation; bronchoconstriction; airway hyperresponsivenessAntiasthmatic drugsAirway inflammation bronchoconstriction
2、Airway hyperresponsivenessImmunological and non-immunological stimuliWheezing (asthmatic symptoms)glucocorticosteroidsdisodium cromoglycateleukotriene modifiers2 receptor agoniststheophyllinemuscerinic antagonists Antiasthmatic drugsAirway pathological changes in pathogenesis of bronchial asthmaAnti
3、asthmatic drugsAirway pathological changes in pathogenesis of bronchial asthmaDrugs used in the treatment of asthma- Classification in Grash Course: Respiratory system (2nd Edition) - Relievers - Bronchodilators 2 agonists short-acting: salbutamol, terbutaline long-acting: salmeterol, formoterol Ant
4、icholinergics (muscarinic antagonists): ipratropine Xantines (theophyllines): aminophylline Preventers - Anti-inflammatory drugs Glucocorticosteroids: Inhaled steroids: beclomethasone, budesonide, fluticasone oral steroids: hydrocortisone, prednisone, dexamethasone Leukotriene (LT) receptor antagoni
5、sts (leukotriene modifiers): LT antagonists: montelukast (孟鲁司特孟鲁司特 ), zafirlukast (扎鲁司特扎鲁司特) 5-lipoxygenase inhibitors: zileuton (齐留通齐留通 ) Inhibitors of mediator release: cromolyn sodium, nedocromilAntiasthmatic drugs Glucocorticosteroids Systemic: hydrocortisone 氢化可的松氢化可的松 prednisone 泼尼松泼尼松 dexamet
6、hasone 地塞米松地塞米松 Inhaled: beclomethasone dipropionate 二二 丙酸倍氯米松丙酸倍氯米松 budesonide 布布 地奈德地奈德 triamcinolone acetonide 曲曲 安奈德安奈德 fluticasone propionate 丙酸氟替卡松丙酸氟替卡松 flunisolide 氟氟 尼缩松尼缩松Adrenocorticoid drugsvAdrenocortical hormonesv Mineralocorticoids v Glucocorticoids v (Glucocorticosteroids)v Sex hormo
7、nes 1. Pharmacological effects Mechanisms of glucocorticoid actions (1) Effects on metabolisms (2) Permissive action (3) Anti-inflammatory effects (4) Effects on immune and allergy (5) Anti-shock (6) Other effects antipyretic effects effects on blood and blood-forming organs skeletal system CNS effectsA. Glucocorticoid drugs
