1、旋毛虫病旋毛虫病（ trichinosis）是由旋毛线虫（ Trichinella spiralis）引起的 人畜共患的寄生虫病 ，流行于哺乳类动物间，人因生吃或半熟食含旋毛虫包囊的猪肉等而感染。1、成虫： 细长，线状，前细后粗2.幼虫囊包 ： 梭形，与肌肉纤维平行，0.250.50.210.42mm大小雌： 34mm，雄： 1.41.6mm内含 12条盘曲幼虫幼虫旋毛虫肌内包囊二、 生活史生活史特点：1. 成虫、幼虫同在一宿主体内，无需体外发育（生物源性线虫）2. 人因吞食幼虫 囊 包 而受感染（经口）3. 有多种保虫宿主人可作为终宿主和中间宿主How Does Trichinella sp
2、iralis Make Itselfat Home?secreted tyvelosylated proteins of the larva play a central role. These proteins are always present in the intracellular niche of the larva from Day 7 after infection and may be responsible for redirecting host genomic expression, leading to nurse cell formation.n (a) Loss
3、of muscle proteins (eg. actin, myosin and creatine kinase). No muscle contractile proteins can be detected beyond Day 8 after the parasite invades the muscle cell. n (b) Enlargement and division of nurse cell nuclei during nurse cell formation. Enlargement of nuclei occurs maximally on Day 8 after the larva invades the muscle cell and nuclei remain enlarged thereafter. Nuclear division and DNA replication occurs during the first 45 days after the larva invades the muscle cell, resulting in 4N DNA in each nucleus and approximately 4060 nuclei per nurse cell.
