1、外科学与免疫学Surgery & Immunology Bing-ya Liu, M.D., Ph. D. , Shanghai Institute of Digestive Surgery 基本概念Basic Principles 免疫 :Immune: protect from pathogens 免疫性Immunity: Capacity of defense infection 免疫应答Immune response : response of recognition and elimination antigenicity foreign material 免疫学 Immunolog
2、y: The science study on the structure & function of the immune systemScience of self-nonself discrimination概念 Concepts 天然免疫与获得性免疫Adaptive and Innate immunity天然免疫 机体与生具有的抵抗外来病原的防御系统无特异性 , 包括Innate immunity Body defenses come from birthAgainst all kinds of pathogens, Not specificIncluding barriersBasi
3、c barrier: skin, mucosaPhysical barrier: body temp, phPhagocytesInflammationAdaptive or Specific Immune response Highly specific for a particular pathogen Specific Muti-type Remember/ memory Transferable 获得性免疫应答具有高度病原特异性特异性多样性记忆性可转移性免疫应答的三个时相Three phases of immune response Recognition: Ag recognized
4、 by lymphocytes Activation: lymphocytes activation Response: Lymphocytes coordinate an immune response that eliminates the source of the Ag识别相激活相效应相免疫系统Immune SystemOrgans of the Immune System免疫器官 Cells of the Immune System免疫细胞 Molecule of the Immune System免疫分子Lymphoid TissuesPrimary lymphoid organs
5、ThymusT cell maturefetal liver Bone marrowSecondary lymphoid organs and tissuesSpleenlymph nodes and lymphatic systemMucosa-associated lymphoid tissue (MALT)B CellCells of the Innate Immune SystemPhagocytesMononuclear phagocytesPolymorphsNeutrophilsEosinophilsBasophils and mast cellsPlateletsNatural killer (NK) cells
