怎样在国际权威杂志上发表科学论文.ppt

How to Publish Your Papers in the Top Scientific Journals鲁白 教授鲁白教授1957年12月生于上海市。1982年 上海 范大 士获 华东师 学学位。学 1990年 康乃尔大 博士 位后，在洛克菲勒大 和哥获 学 学 学比 大 事博士后 究伦 亚 学从 研 ,导师为Paul Greengard和蒲慕明教授。1993年加入 氏分子生物 究所， 任哥 比 大 助罗 学研 并 伦 亚 学理 授。教 1996年加入NIH 童健康和人 育 究所，任突儿 类发 研 触育和可塑性 究室主任。发 研主要 究神 因子在突 育和可塑性中的作用。研 经营养 触发他的 究室是最早提出 神 因子 神 系 突 、研 并发现 经营养 对 经 统 触传递突 育可塑性有 控作用的 室之一， 几 著名 室一触发 调 实验 与 个 实验起 了神 因子的突 控 一新 域。开创 经营养 触调 这 领Bai Lu 怎 样 在 国 际 权 威 杂 志 上 发 表 科 学 论 文 鲁 白鲁 迅 Lu Xun(1881-1936)The father of modern Chinese literaturesThe most influential poet in Chinese history李 白 Li Bai(701-762)1. M. F. Egan, M. Kojima, J. H. Callicott, T. E. Goldberg, B. S. Kolachana, E. Zaistev, A. Bertolino, B. Gold, D. Goldman, M. Dean, B. Lu, (co-corresponding author) and D. R. Weinberger. (2003) The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112, 257-269. 2. L. Ma, Y. -Z. Huang, J. Valtschanoff, L. Feng, B. Lu, W. Xiong, R. Weinberg, L. Mei. (2003) Ligand-dependent recruitment of the neuregulin signaling complex into neuronal lipid rafts. J. Neurosci. 23, 3164-3175. 3. J. Wang, C. -Q. Chen, B. Lu, and C. -P. Wu. (2003) GDNF acutely potentiates Ca2+ channels and excitatory synaptic transmission in midbrain dopaminergic neurons. NeuroSignals 12, 78-88. 4. M. Miura, S. Gronthos, M. Zhao, B. Lu, L. W. Fisher, P. G. Robey, and S. Shi (2003) SHED: Stem cells from human exfoliated deciduous teeth. Proc. Natl. Acad. Sci. USA 100, 5807-5812. 5. Y. X. Zhou, M. Zhao, K. Shimazu, K. Sakata, D. Li, C. -X. Deng, B. Lu. (2003) Impairments in cerebellum Purkinje cells and motor function in mice lacking Smad4 in the central nervous system. J. Biol. Chem. 278, 42313 - 42320. 6. J. Du, L. Feng, E. Zaitsev, H. S. Je, X. Liu, and B. Lu. (2003) Activity- and tyrosine kinase-dependent facilitation of TrkB receptor internalization in hippocampal neurons. J Cell Biol. In press. 7. Z. G. Luo, H. -S. Je, F. Yang, W. C. Xiong, B. Lu, and L. Mei (2003) Activation of geranylgenanyltransferase is essential for Agrin-induced AChR clustering. Neuron In press. 8. S. X. Bamji, K. Shimazu, N. Kimes, J. Huelsken, W. Birchmeier, B. Lu, L. F. Reichardt. (2003) Regulation of presynaptic assembly and maintenance by -catenin. Neuron In Press.9. F. Yang, X. He, J. Russell, and B. Lu. (2003) Ca2+ influx independent transmitter release mediated by mitochondrial Na+-Ca2+ exchanger and protein kinase C. J. Cell Biol. In press. 2003 research articlesWhat Is the Purpose of Doing Research?It is not about the number of papersIt is not about the impact factor of the papersIt is not about the Nobel Prize Publish or perish1 Nature = 10 JBCBasic Elements for Basic ResearchPassion 6 Sigma Silver bullet testGood Research Is the Key My English is not good They are biased against Chinese (foreigners) 人家没做过  你就要做 这是新的 = 这是好的What Is a First-Class Paper/Research? Major advance in a classic field干细胞是如何分化成特定组织细胞的，胆固醇在人体的正常功用 New techniques and methods that can be widely used人类基因组研究中的自动测序技术 , PCR, Patch clamp, Ca2+ Imaging, GFP Discoveries with obvious practical implicationsAIDS virus receptor 的发现, 老年痴呆症基因的发现  Conceptual breakthrough, novel ideas神经营养因子可以促进学习记忆, RNA干 现  Challenge to traditional views, break dogma可分 的神经干细胞， 传统  Opening up new area, cross board细胞 现 的发现, 开 新的科研领 What Is a Mediocre Paper/Research?• Horizontal growthI made the discovery in rats, you find the same in cat.• Filling gapsEGF activates JNK which is known to induce c-Jun expression. You show that EFG enhances c-Jun expression. • Working out detailsI found NO induces the production of cGMP, you work out dose response and time course.• Support existing idea, “me too”EGF-R endocytosis requires dynamin, PDGF-R too.• Follow up CREB binds to CRE. Working out CRE sequence.• Incomplete study, preliminaryHow to Read Scientific Papers?• The Gilbert way• Keep these in mind when you read• What is the major question addressed in this paper? • Is this question important and why?• What are the approaches used in this paper, and whether they are adequate for the questions?• What are the novel idea or using innovative approaches?• What is the concept coming out of this paper?• Do the results presented support this new concept? • Weekly reading of CNS titles• Critical, appreciative