1、Electroacupuncture neurostimulation for treatment of chronic voiding dysfunction电针神经刺激疗法治疗慢性排尿障碍,Prof. Wang SiyouShanghai Research Institute of Acupuncture and Meridian,Stress Urinary Incontinence压力性尿失禁,Urinary incontinence can be classified under 7 types in Western medicine 尿失禁在西医可分为7种类型。,Stress ur
2、inary incontinence (SUI)压力性尿失禁Urge urinary incontinence (UUI)急迫性尿失禁Unconscious urinary incontinence无意识性尿失禁 Continuous urinary incontinence持续性尿失禁,Nocturnal enuresis夜间遗尿Postvoid dribble排尿后滴尿Overflow urinary incontinence 充盈性尿失禁,Stress urinary incontinence (SUI) is defined as an involuntary leakage of u
3、rine from the urethral meatus at a sudden increase in intra-abdominal pressure (eg coughing, sneezing, laughing, running or strenuous activities) without simultaneous detrusor contraction. 压力性尿失禁是指平时无尿失禁状态下，当腹压骤增时（如咳嗽、打喷嚏、大笑、奔跑、剧烈活动）尿液不自主从尿道口流出，同时不伴有膀胱逼尿肌收缩。,It often happens in multiparous and postm
4、enopausal women.It comes under the category of enuresis in TCM.临床多见于中年已生育的妇女。属中医学遗尿范畴。,Stress Urinary Incontinence,Overactive bladder & Urge incontinence,EtiologyThe possible causes of stress urinary incontinence (SUI) are: (1) childbirth and puerperal injury, and dystocia, especially forceps delive
5、ry; (2) changes in the urethra and periurethral tissues, eg atrophy of pelvic floor tissues due to postmenopausal changes in sex hormones;一. 病因可能的发病原因有：（1）分娩及分娩损伤，难产、产钳操作尤甚；（2）尿道及尿道周围组织改变，如绝经后性激素改变致盆底组织萎缩；,Etiology(3) history of vaginal, urethral or prostatic surgery; (4) perineal or urethral injury
6、; (5) pelvic tumescence resulting in a high intra-abdominal pressure and a lower position of bladder neck. More than one cause may coexist.（3）阴道、尿道及前列腺手术史；（4）会阴部及尿道损伤；（5）盆腔内肿物致腹压增高，膀胱颈位置降低。一个或多个病因可同时存在。,PathogenesisThe above etiologies produce the abnormalities of (vesical neck and urethra) sphincte
7、rs, that is, urethral hypermobility or/and intrinsic sphincter deficiency (intrinsic malfunction of the urethral sphincter itself) to result in SUI. 二. 发病机理上述原因可引起（膀胱颈和尿道）括约肌异常：尿道活动度增大或/和括约肌内在缺陷（尿道括约肌本身的内在机能异常，近端尿道失去括约肌作用），导致压力性尿失禁。,PathogenesisIn the former, a weakness of pelvic floor support cause
8、s the hypermobility and descent of the vesical neck and proximal urethra during an increase in intra-abdominal pressure and thereby unequal transmission of abdominal pressure to the bladder and urethra (vesicourethral pressure transmission ratio decreases); when vesical pressure exceeds urethral pre
9、ssure, incontinence ensues .前者是由于盆底支持组织松弛引起膀胱颈部和近端尿道在腹压增加时活动度增大、向下移位，导致膀胱尿道压力传递比降低，膀胱内压暂时高于尿道内压，于是发生尿失禁。,Subtypes of stress incontinence压力性尿失禁的亚分类,There are 2 possible reasons for urodynamic stress incontinence:尿流动力学压力性尿失禁的2个可能原因“Hypermobility” “过度移动症 ”(weakness of bladder support) （薄弱的膀胱支持力 ）“Intri
10、nsic sphincter deficiency” “固有括约肌功能障碍” (“ISD” - weakness of urethral sphincter) (“ISD”尿道括约肌力弱)Video or extra tests (UPP, VLPP) help to make this distinction影像技术及其他辅助检查（ 尿道压力描计 UPP，屏气时漏尿点压力VLPP）有助于区分,腹压升高,漏尿,尿道无力,Stress Urinary Incontinence,Stress Incontinence: VLPPRest & Straining,Q Tip TestTest for
11、 mobility30 degreeSimple CMGUrethral catheterManometer orToomey Syringe,Simple Tests,Clinical manifestations1.SymptomInvoluntary loss of urine during coughing, sneezing, laughing, running or physical exertion such as sport activities and sudden changes of position.三.临床表现1.症状咳嗽、打喷嚏、大笑、奔跑或体育活动、突然改变体位等
12、身体用力时尿液不自主从尿道口流出。,Clinical manifestations2.SignsThe observation of loss of urine from the urethra during coughing, sneezing, or physical exertion. Positive Marshell (bladder base elevation) test.Positive pad test.A vaginal examination shows cystocele, enterocele or rectocele.2.体征咳嗽、打喷嚏或身体用力时观察到尿液从尿道
13、口流出。指压（尿道抬举）试验阳性。护垫试验阳性。阴道检查可见膀胱、肠、直肠膨出。,Video-urodynamics1.Urethral hypermobility The vesical neck is closed at rest (no increase in intra-abdominal pressure). During stress (an increase in intra-abdominal pressure), the vesical neck and proximal urethra open and descend.四.影象尿动力检查1. 尿道活动度增大 静止（无腹压增
14、加）时，膀胱颈关闭；应力（腹压增加）时，膀胱颈和近端尿道开放和下移。,Video-urodynamics2.Intrinsic sphincter deficiency The vesical neck and proximal urethra are open at rest in the absence of detrusor contraction.2.括约肌内在缺陷 静止、无逼尿肌收缩时，膀胱颈（和近端尿道）开放。,Hypermobility (type II incontinence)过度移动症（II型尿失禁）,Easily defined on videourodynamics通过
15、影像尿流动力学很容易确定but Q-tip test or simple observation will help但 Q-tip 试验及简单的观察有助于诊断,Hypermobility过度移动症 (on cough or Valsalva, or permanent descent)（咳嗽，Valsalva，或者持续下降）,正常,LPP measurement漏尿点压力测量,Strain: leaks at 165 cm H2O用力屏气:在 165 cm H2O时漏尿,（活动过度）(hypermobility),Hyper-mobility with leakage (on cough) 活
16、动过度伴漏尿（在咳嗽时）,Start filling开始充盈,Stop fill at 200 ml在 200 ml时停止充盈,Strain: leaks at 45 cm H2O用力屏气:在 45 cm H2O时漏尿,LPP measurement漏尿点压力测量,Initial pves初始膀胱压,(no hypermobility, ISD)（无过度移动症，固有括约肌功能障碍）,DagnosisBased onThe symptom (history) of stress incotinencePositive stress test (loss of urine during cough
17、ing or physical exertion) and Marshell test or pad test.五. 诊断根据：1. 压力性尿失禁症状（病史）。2. 应力试验阳性（咳嗽或用力腹压增高时有漏尿）和指压试验阳性或护垫试验阳性。,DagnosisBased onThe results of imaging urodynamic examination: urethral hypermobility or/and intrinsic sphincter deficiency ; no involuntary detrusor contraction. 3. 影象尿动力检查结果：尿道活动
18、度增大或/和括约肌内在缺陷；无逼尿肌无抑制性收缩。,Treatment1. Western conservative treatment Conservative treatment can be applied to mild and moderate SUI. Its advantages are safety, micro invasion, and much lower incidence and less severity of complications compared with surgical treatment.六.治疗方法1. 西医保守治疗对于轻、中度压力性尿失禁可采用保
19、守治疗，其优点是安全微创，并发症的发生率和严重程度远低于手术治疗。,1. Western conservative treatment Conservative treatment mainly includes pelvic floor muscle exercises (PFME), electrical stimulation (ES), various vaginal and urethral devices and medication. PFME and transvaginal or trans-anal ES (TES) are the two most commonly us
20、ed forms of conservative treatment for SUI.保守治疗主要包括盆底肌锻炼、电刺激、各种阴道和尿道装置及药物治疗。其中盆底肌锻炼和经阴道或肛门电刺激（被动的盆底肌锻炼）是最常用的二种治疗方法。,1. Western conservative treatmentPFME can build up the structural support of the pelvis, improve neuromuscular function, prevent the proximal urethra and bladder base from descending d
21、uring a rise in abdominal pressure and increase urethral pressure. 盆底肌锻炼具有增强盆底肌肉支持力量，改善神经肌肉功能，阻止腹内压增高时近端尿道和膀胱底部下降及增加尿道压的作用。,1. Western conservative treatmentIts shortcomings are many patients difficulty identifying and isolating their PFM and inability to perform PFME effectively; lack of long-term
22、patient compliance. 缺点是：许多患者不能正确收缩盆底肌；依从性差。,1. Western conservative treatmentTES is passive PFME that produces PFM contractions and has good patient compliance. Its shortcoming is that it applies vaginal or anal surface electrode and induces PFM contractions by indirect nerve stimulation, so its eff
23、ect is not as good as that of PFME which is done correctly. 经阴道或肛门电刺激是被动的盆底肌锻炼，有很好的依从性。缺点是：因使用表面电极，作用是间接的，效果不及正确的盆底肌锻炼 。,2. Acupuncture treatmentAcupuncture of traditional Chinese medicine can also be applied to mild and moderate stress incontinence. Its advantages are safety, convenience, and no si
24、de effects and complications. 2. 中医针刺治疗对于轻、中度压力性尿失禁也可采用中医针刺治疗，其优点是安全、方便、无副作用和并发症。,2. Acupuncture treatment1) Therapeutic principleAccording to TCM theory, it is caused by deficiency of kidney qi and failure of the bladder in restraining the urine discharge, so the therapeutic principle is reinforcin
25、g kidney qi and improving vesical restraining function.1) 治疗原则 中医认为，尿失禁是由于肾气不足，膀胱不固引起，因此治疗原则是补益肾气，固脬止遗。,2) Point selectionThe Back-Shu and Front-Mu points of the kidney and bladder are selected as the main acupoints. The acupoints often selected are Shenshu (B 23), Pangguangshu (B 28), Zhongji (Ren
26、3), Guanyuan (Ren 4), Mingmen (Du 4), Huiyang (B 35), Sanyinjiao (Sp 6) and Zusanli (S 36).2) 穴位选择主穴是肾和膀胱的背俞穴和募穴。常用穴位有：肾俞，膀胱俞，中极，关元，命门，会阳，三阴交，足三里。,2) Point selectionThe kidney is exteriorly-interiorly related to the bladder, so the Back-Shu points of the kidney and bladder are applied. Zhongji (Ren
27、3) is the Front-Mu points of the bladder. The combined use of the above three acupoints contributes to reinforce kidney qi and improve vesical restraining function.肾和膀胱相表里，故选肾和膀胱的背俞穴。中极是膀胱的募穴。三穴合用有助于补益肾气，固脬止遗。,2) Point selectionGuanyuan (Ren 4) and Mingmen (Du 4) are the sources of primordial qi and
28、 acupuncture of them can tonify primordial yang (kidney-yang). Huiyang (B 35) is the acupoint of the foot-taiyang meridian and acupuincture of it can invigorate the meridional qi of the bladder. 关元、命门是元气之源，针之能补肾益元。会阳是足太阳经穴位，针之能振奋膀胱之经气。,2) Point selectionSanyinjiao (Sp 6) is the crossing point of the
29、 three foot-yin meridians and acupuncture of it can regulate the qi of the three foot-yin meridians. Zusanli (S 36) belongs to the yangming meridian, which is full of qi and blood, and acupuncture of it can tonify qi to stop incontinence.三阴交是足三阴经交会穴，针之能调节足三阴经气。足三里属阳明经，阳明经多气多血，针之能补气止遗。,3) Shortcoming
30、Because it uses a general method of acupuncture, it is difficult for conventional acupuncture, like electrical nerve stimulation, to improve the ability in controlling urination by exciting the pudendal nerve, inducing the rhythmic contraction of the pelvic floor muscles and increasing their strengt
31、h. 3) 不足之处因采用一般针刺方法，故难以象神经电刺激疗法那样通过兴奋阴部神经诱发盆底肌节律性收缩，增强盆底肌肉力量来改善控尿能力。,3. Electroacupuncture pudendal nerve stimulationBy combining the advantages of PFME and TES and incorporating the technique of deep insertion of long needles, we developed electracupuncture pudendal nerve stimulation ( “Four sacral
32、 points” electracupuncture therapy), which is a combination of traditional Chinese and Western medicine. 3. 电针阴部神经刺激疗法综合PFME 和 TES二种疗法优点，融入针灸长针深刺技术，我们发展成了(中西医结合的)电针阴部神经刺激疗法（电针“骶四穴”疗法）。,3. Electrical pudendal nerve stimulation In this therapy, four sacral specific points are acupunctured by a special
33、 needling method (the needle tip in a specific direction) and electrified3. 电针阴部神经刺激疗法该疗法对骶部四个特定穴位采用特殊针刺方法（针尖向特定方向）并加以电刺激,3. Electrical pudendal nerve stimulationto improve the ability in controlling urination by exciting the pudendal nerve and inducing the rhythmic contraction of the pelvic floor m
34、uscles (including the urethral sphincter ) to strength the muscles, restore the normal positions of bladder neck and proximal urethra and increase urethral closure pressure. 能直接兴奋阴部神经诱发盆底肌（包括尿道括约肌）节律性收缩，从而增强盆底肌肉力量，恢复膀胱颈部和近端尿道的正常位置，提高尿道关闭压来改善控尿能力。,Four sacral points骶四穴,Location of four sacral points
35、and acupuncture methods1) The two upper points: located by the two edges of the sacrum on a level with the fourth sacral foramina;定位和针刺方法1）上两针刺点：骶骨边缘旁，平第4骶后孔水平处（双侧）。,Four sacral points骶四穴,Location of four sacral points and acupuncture methods1) The two upper points: use a long needle of 4 cun (100mm
36、); puncture perpendicularly 33.5 cun in depth; make the needling sensation reach the urethra or anus.使用4寸长针直刺，针刺深度为3-3.5寸，使针感达尿道或肛门。,Four sacral points骶四穴,Location of four sacral points and acupuncture methods2) The two lower points: 0.5 cun bilateral to the tip of the coccyx; use a long needle of 4
37、 or 5 cun (100 or 125mm); 2）下两针刺点： 尾骨旁开0.5寸（双侧），使用4寸或5寸长针，,Four sacral points骶四穴,Location of four sacral points and acupuncture methods2) The two lower points: puncture obliquely (laterally) towards the ischiorectal fossa, 34.5 cun in depth; make the needling sensation reach the urethra.向外侧（坐骨直肠窝）斜刺
38、，3-4.5寸深，使针感达尿道。,Electrical pudendal nerve stimulation After the needling sensation referred to the above regions was produced, a G6805-2 Multi-Purpose Health Device was connected with the inserted needles used as electrodes. The device was set to produce an electrical stimulation at a frequency of
39、2.5 Hz (150 times/min) and an intensity as high as the patient could tolerate without discomfort. The electroacupuncture was set for 60 minutes each time. 3. 电针阴部神经刺激疗法针感达特定部位后接G6805治疗仪。电针采用连续波，频率约2.5Hz (150次/分），强刺激以患者不感到难受为度，每次持续60分钟。,Electrical pudendal nerve stimulationStrong rhythmic and cephalad contraction of the pelvic floor muscles around the urethra must be kept during the electroacupuncture. The treatment was given once every other day. The treatment course was based on the patients condition.电针期间需保持盆底肌以尿道为中心有节律地向上（头部方向）强烈收缩的感觉。治疗隔日1次，治疗次数视病情而定。,会阴超声、阴道压力同步检测,Accessories,Thanks,
