1、GEM S.r.l.Via dei Campi, 2 PO Box 427 55049 Viareggio (LU) ItalyTel. +39 0584 389784/391388 Fax +39 0584 397904 Web: www.gemitaly.it E-Mail: info.gemitaly.it,GLUBRAN2外科应用,GLUBRAN2,心脏外科,二尖瓣,GLUBRAN2 心脏外科,上腔静脉,肺动脉瓣,三尖瓣,下腔静脉,右心室,肺动脉,肺静脉,二尖瓣,主动脉瓣,左心房,左心室,右心房,心内膜,心肌,心外膜(心包内侧),心包间隙,心包顶部,纤维心包,冠状动脉,GLUBRAN2
2、 心脏外科,动脉,内膜,中膜,外膜,内皮,基底层,内弹力膜(弹性结缔组织),平滑肌组织,营养神经的血管,结缔组织的胶原纤维,弹性膜(弹性结缔组织),静脉,内膜,中膜,外膜,内皮,基底层,平滑肌纤维与弹力纤维混合,结缔组织的胶原纤维,内皮,毛细血管,基底层,“燕巢”阀门,这种手术怎么做?将患者一部分自体血管缝合在梗阻的下游,另一端与梗阻的上游连接,冠状动脉旁路,GLUBRAN2 应用,Glubran 2用作: 止血剂,加强吻合粘合剂,在冠脉的心脏旁路手术中优化与加固通路,主动脉-冠状动脉旁路,梗阻,定义:主动脉内膜撕裂伴中膜破损,随后内膜与外膜分离,形成另一血流(假腔),主动脉夹层,GLUBRA
3、N2 应用,Glubran 2 用作:在急性主动脉夹层中用作粘合剂,粘合切口平面在急性主动脉夹层中用作止血剂/密封剂,进行近端和远端吻合在急性主动脉夹层中用作加强贴片的粘合剂加固主动脉与血管的缝合,中膜,外膜,内膜,血液进入的内膜撕裂处,高压血液流动的真腔,正常,主动脉夹层,血管假体,血,胸腔主动脉瘤,Glubran 2 用作:在各种主动脉瘤手术中用作吻合处的止血剂/密封剂加固主动脉与血管的缝合,GLUBRAN2 应用,术前,升主动脉瘤,冠脉扣,术后,管状移植修复件,缝合线,主动脉瓣,重新移植在管状修复件内的主动脉瓣,Glvez-Montn C et al. Transposition of
4、a pericardial-derived vascular adipose flap for myocardial salvage after infarct; Cardiovasc Res. 2011 Sep 1;91(4):659-67GomesW J et al.Treatment of Delayed Rupture of the Left Ventricle After Mitral Valve Replacement; Arq. Bras. Cardiol.vol.79no.5So PauloNov.2002 CASE REPORTAlamanni F et al.Suturel
5、ess double-patch-and-glue technique for repair of subacute left ventricular wall rupture after myocardial infarction; J Thorac Cardiovasc Surg 2001;122:836-7Gargiulo G et al.A New Patch for the Norwood Procedure; Ann Thorac Surg 1999;68:18734De Paulis R et al. Cyanoacrylate glue as an alternative to
6、 an additional suture line in the repair of type A aortic dissection; Tex Heart Inst J. 1999;26(4):275-7. Birdi I et al.Left ventricular volume reduction surgery; International Journal of Cardiology 62 Suppl. 1 (1997) S29S35,GLUBRAN2 心脏外科,参考书目,Glvez-Montn C et al. Transposition of a pericardial-deri
7、ved vascular adipose flap for myocardial salvage after infarct; Cardiovasc Res. 2011 Sep 1;91(4):659-67,GLUBRAN2 心脏外科,参考书目,目的评价自心包膜分离血管脂肪瓣,并固定在冠状动脉梗塞后的心肌梗死区的效果。,结果开发了分离猪心脂肪瓣,并转移至心肌梗死区的手术。用Glubran 2 (0.1-0.2 ml固定脂肪瓣边缘,并以组织学和生化学分析评价脂肪瓣在梗死区的固定效果。,Glvez-Montn C et al. Transposition of a pericardial-derived vascular adipose flap for myocardial salvage after infarct; Cardiovasc Res. 2011 Sep 1;91(4):659-67,GLUBRAN2 心脏外科,参考书目,结论梗死区的血管脂肪瓣有利于: 应用部位的功能 限制心肌重塑将来的研究需确证该手术是否可作为一种替代疗法,挽救心脏病发作后的心肌。,具有心脏外科适应症的封闭剂竞争者剖析,GEM,