1、Haploidentical Hematopoietic Stem Cell Transplantation for Hematological Malignancies Xiao-Jun Huang M.D. Ph.D. Peking University Institute of Hematology, Peking University Peoples Hospital 15:4777-4783 Huang XJ, et al. BBMT. 2011 Jun;17(6):821-30. 3. Unmanipulated Haploidentical HSCT Effects of G-C
2、SF on Bone Marrow in Healthy Donors HuangXJ, et al. Clin Transplant 2011: 25: 1323 3. Unmanipulated Haploidentical HSCT Immunoregulatroy Effects after G-CSF Administration to Healthy Donors Huang XJ, et al. Biol Blood Marrow Transplant.2011;17(2):197-204 3. Unmanipulated Haploidentical HSCT Engraftm
3、ent Huang XJ, et al. Biol Blood Marrow Transplant,2009, 15(5):632-8 n=348 P=0.008 n=348 CD34+ cells2.19 106/kg CD34+ cells2.19 106/kg P0.0001 Early stage Advanced stage 3. Unmanipulated Haploidentical HSCT Characteristics of the Allo-Grafts Summary Statistics TNC 108/kg CD34+ 106/kg CD3+ 108/kg CD4+
4、 107/kg CD8+ 107/kg CFU-GM 105/kg BM Range 1.2 8.3 0.2 8.8 0.1 1.1 0.4 7.3 0.3 3.7 1.39.4 Median 3.53 1.39 0.20 1.10 1.08 2.62 PB Range 1.9 9.2 0.6 6.6 0.6 6.6 1.9 39.0 2.9 29.7 1.410.5 Median 4.02 1.58 1.46 8.76 7.01 3.03 T Range 5.214.2 0.8 13.4 0.8 6.7 3.339.6 3.729.6 2.2 19.9 Median 7.56 2.65 1.
5、77 10.39 7.87 5.21 Huang XJ, et al. Bone Marrow Transplant, 2006, 38:291 3. Unmanipulated Haploidentical HSCT Huang XJ, et al. Biol Blood Marrow Transplant 2009, 15(2) Huang XJ, et al. Biol Blood Marrow Transplant 2011; 17(6) Cumulative incidence of aGVHD after HLA-mismatched allo-HSCT Haplo=81 Identical=36 P=0.11 3. Unmanipulated Haploidentical HSCT
