1、摄食调节机制Control of Food Intake,夏 强，PhD浙江大学医学院生理学系医学院科研楼C座518室电话：88206417, 88208252Email：,摄食活动及相关中枢,摄食调节机制至今尚未完全阐明摄食的启动主要来自生理需要：食物色香味的刺激胃肠道的空置血液中营养物质的浓度降低心理因素等摄食行为一般由摄食中枢和饱中枢控制摄食中枢hunger center：下丘脑外侧区饱中枢satiety center：下丘脑腹内侧区,Lateral hypothalamus (hunger center): animals with lesions in this area becom
2、e anorectic and lose weight.Ventromedial hypothalamus (satiety center): animals with lesions in this area overeat and become obese.,营养物质的消化产物具有调控作用,葡萄糖：可能通过增加饱感调控摄食活动血糖低于一定阈值可引起饥饿感，并激发摄食行为血糖恢复，摄食停止氨基酸：对摄食的调节不如葡萄糖稳定血氨基酸浓度增加可使动物摄食减少，反之摄食增加脂肪代谢产物：摄食程度与体内脂肪组织量成反比FFA及其他脂肪代谢产物增加摄食减少，反之增加,多种神经神经递质参与摄食调节,促进
3、摄食活动：去甲肾上腺素，多巴胺，阿片肽，胰多肽，肥胖素（增食因子，orexin），饥饿素（ghrelin）等抑制摄食活动：缩胆囊素（CCK），蛙皮素，神经降压素，瘦素（leptin）等,Summary of mechanisms controlling food intake. Peripheral stimuli and inhibitors, release in anticipation of or in response to food intake, cross the blood-brain barrier (indicated by the dotted line) and ac
4、tivate the release and/or synthesis of central factors in the hypothalamus that either increase or decrease subsequent food intake. Food intake can also be modulated by signals from higher centers, as shown. Not shown, peripheral orexins can reduce production of central inhibitors, and vice versa.,谢谢！,
