1、Antibiotics in Coastal Waters of Northern China: Occurrence and Environmental Risk,Reporter：Jian-rong ZhangCollege of Environment and Resources, Dalian Minzu University2018.5.18ChinaZhuhai,CONTENTS,Introduction,In recent years, antibiotic pollution has become more serious in the coastal waters of Ch
2、ina. This paper summarizes the distribution of antibiotic pollution in the coastal waters of northern China (Bohai Bay, Laizhou Bay, and the northern Yellow Sea coast), calculates and evaluates the environmental risk level, And provide advice and guidance for marine conservation,Antibiotics are orga
3、nic substances that selectively inhibit or affect biological functions at low concentration. Since Fleming first discovered the antibiotic penicillin in 1929 , more and more antibiotics have been discovered.,Introduction,Introduction,As an important drug for preventing and treating many common disea
4、ses in humans and animals，it is widely used in the medical industry and animal husbandry. However, they are not completely absorbed by the organism and 90% of the antibiotics are excreted in the form of metabolites through the feces and urine and are directly or indirectly introduced into the natura
5、l world.,antibiotic resistance genes,Harm,antibiotic will promote the development of antibiotic resistance genes (ARGs) in bacterial populations.,Biological toxicity,In addition, antibiotics have toxic effects on marine ecosystem animals, 80% of which are toxic to algae, and more than 50% of antibio
6、tics are toxic to fish.,Harm human health,Toxic injury (2) Allergic reaction or allergic reaction(3) Three effects, namely carcinogenic, teratogenic, mutagenic,Introduction,Chinese Antibiotic Use Status,CONTENTS,您的内容打在这里，或者通过复制您的文本后，在此框中选择粘贴，并选择只保留文字。您的内容打在这里，或者通过复制您的文本后，在此框中选择粘贴，并选择只保留文字。您的内容打在这里，或
7、者通过复制您的文本后，在此框中选择粘贴，并选择只保留文字。,Sampling Site,Analysis Method,Assessment of the potential environmental risks of antibiotics in the aquatic environment based on the Risk Quotient (RQ) in the European Risk Assessment Technical Guidance Document . The individual RQ was calculated by dividing the measure
8、d actual concentration (MEC) of the predicted ineffective concentration (PNEC) .,RQ = MEC/PNEC. PNEC is calculated based on the toxicity data.The estimated risk level can be divided into four categories, namely no risk (RQ1).,CONTENTS,Antibiotic Types in Coastal Waters in Northern China,Study found
9、that within the study area, total of 29 antibiotics were detected, include five main types. And in this picture shown the Antibiotic Types in Coastal Waters in Northern China. We can find out the North Yellow Sea has the largest number of antibiotics, up to 17 species.,Antibiotic Concentration in Co
10、astal Waters in Northern China,But in this picture, We can find the North Yellow Sea the total average concentration is very low. The concentration of antibiotics in Laizhou Bay and Bohai Bay in the Bohai Sea is relatively high. The total average is as high as 219ng/L and 180ng/L,Environmental Risk
11、in Coastal Waters in Northern China,CONTENTS,Conclusions,Discuss,The above analysis shows that the status of antibiotic pollution in the coastal waters of northern China is relatively serious, and the Bohai region has a high concentration of antibiotics and is relatively high due to the fact that it
12、 is a closed inland sea, and there are many rivers flowing into the sea, and the resident population is dense. Environmental risks pose a certain potential threat to human health. Therefore, we need to control the use of antibiotics in coastal areas and adopt rational and effective antibiotic degrad
13、ation methods.,Prospect,Related studies have shown that plants have a strong role in the transfer of antibiotics. And our next research content is mainly to explore the selection of antibiotic contaminated plants that are suitable for northern coastal wetlands, and to conduct a systematic study of i
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16、 H.M. Li, W. Zhang, J.R. Hu, Y.C. Ke, W.L. Sun, J.R. Ni: Science of the Total Environment. Vol. 615 (2018) , p. 9069178D.M. Cheng, Y.J. Xie, Y.J. Yu, X.H. Liu, S.N. Zhao, B.S. Cui, J.H. Bai: Wetlands. Vol. 36 Suppl 1 (2016), p. S167S1799R. Zhang, G. Zhang, Q. Zheng, J. Tang, Y. Chen, W. Xu, Y. Zhou,
17、 X. Chen: Ecotoxicology and Environmental Safety Vol. 80 (2012b), p. 208-215.10G.S. Na, X.D. Fang, Y.Q. Cai, L.K. Ge, H.M. Zong, X.T. Yuan, Z.W. Yao, Z.F. Zhang: Marine Pollution Bulletin. Vol. 69 (2013), p. 233237,References,THANKS！,Reporter：Jian-rong ZhangCollege of Environment and Resources, Dalian Minzu University2018.5.18ChinaZhuhai,
