1、 Key PointPatients with residual symptoms have a higher risk of recurrence BackgroundThis study compared the time to recurrence in patients with unresolved depressive symptoms (n=82) and asymptomatic patients (n=155) over a 10-year periodAsymptomatic patients were defined in the study as having a Ps
2、ychiatric Status Rating of 1Patients with residual symptoms had a greater chance of relapse/recurrence compared with asymptomatic patients (86.6% vs. 65.8% had relapse or recurrence, respectively)In addition, relapse occurred more than 3 times faster (median: 23 weeks vs. 68 weeks) in patients with
3、residual symptomsRapid recurrence in the symptomatic group could not be attributed to higher comorbidity or lower dose of antidepressant drugsReferenceJudd LL, Akiskal HS, Maser JD, et al. Major depressive disorder: a prospective study of residual subthreshold depressive symptoms as predictor of rapid relapse. J Affect Disord. 1998;50:97-108.
