1、Reciprocal Repression between MicroRNA-133 and Calcineurin Controls Cardiac Hypertrophy: A Novel Mechanism for Progressive Cardiac HypertrophyDe-Li Dong, Yan-Jie Lu, Bao-Feng Yang(董德利 吕延杰 杨宝峰 )Department of PharmacologyHarbin Medical University, P.R.China Aug.20-22,2009.Dalian Backgroundo Calcineuri
2、n/NFAT pathway induces Cardiac Hypertrophy o Calcineurin activation in cardiac hypertrophyo Decreased miR-133 expression in cardiac hypertrophy o Overexpression of miR-133 inhibits cardiac hypertrophy o Inhibition of miR-133 induces cardiac hypertrophyAug.20-22,2009.Dalian 1. Calcineurin-Dependent C
3、ardiac HypertrophyJeffery D. Molkentin et al. Cell,1998; 93,215228. Aug.20-22,2009.Dalian 1. Calcineurin-Dependent Cardiac HypertrophyJeffery D. Molkentin et al. Cell,1998; 93,215228. Aug.20-22,2009.Dalian 1.Calcineurin-Dependent Cardiac HypertrophyJeffery D. Molkentin et al. Cell,1998; 93,215228. A
4、ug.20-22,2009.Dalian Overexpression of calcineurin in mouse causes sudden cardiac death associated with decreased density of K channelsDeli Dong. et al. Cardiovascular Research 57 (2003) 320332Aug.20-22,2009.Dalian 2. Calcineurin Activation in cardiac hypertrophyHae W. Lim et al.Circulation. 2000;10
5、1:2431-2437.Aug.20-22,2009.Dalian 3. Calcineurin/NFAT Coupling Participates in Pathological, butnot Physiological, Cardiac HypertrophyWilkins BJ, et al. Circ Res. 2004;94:110-118.Aug.20-22,2009.Dalian Car A et al. Nat Med. 2007;13(5):613-8. 4. Decreased miR-133 expression in cardiac hypertrophyAug.20-22,2009.Dalian 5. Overexpression of miR-133 inhibits cardiac hypertrophyCar A et al. Nat Med. 2007;13(5):613-8. Aug.20-22,2009.Dalian
