1、l 抗菌药物 l 抗菌药物的抗菌类型及抗菌机理l 细菌的耐药性l 细菌的耐药机理l 细菌耐药性的控制策略抗菌药物Antibiotics （抗生素）其他抗菌物Bacteriophage （噬菌体）Bacteriocin （细菌素）Lysozyme （溶菌酶）Antibiotics (抗生素 ) Antibiotics （抗生素）由真菌、放线菌或细菌 自然代谢 产生的可 杀死 或 抑制 微生物生长的物质 Synthetic antibiotics （合成抗生素）在实验室中，通过 化学合成 生产的可 杀死或 抑制 微生物生长的物质Discovery Penicillin the first natu
2、ral antibiotics produced by Penicillium notatm identified by Alexander Fleming in 1928Alexander FlemmingAcquired Noble prize in 1945 Pencillin was purified and tested in mice showing its therapeutic action against lethal bacteria infection in 1935by Howard Florey and Emst Chain Alexander Flemming Ho
3、ward Florey acquired Noble prize in 1945Emst Chain Streptomycin was identified by Selman Waksman in 1944acquired Noble prize in 1952Large-scale production of Penicillin by U.S pharmaceutical companies in early 1940s Hundreds and thousands of live of infected soldiers were saved by the end of W.W.II Screening and discoveries of many other kinds of antibiotics in 1950s and 1960s Microbes began developing resistance against the wonder drugs 抗生素的种类
