1、识别活化效应免疫应答的三个阶段Overview of generation of T cell and T cell responses in vivo 应答诱导淋巴器官内抗原识别T细胞扩增和分化分化的细胞进入循环效应 T细胞和其他白细胞迁移到感染部位在 外周 效应 T细胞遭遇抗原效应 T细胞活化T细胞的效应功能Types of adaptive immune responses. T cell subsetsTypes of cell-mediated immune reactionsq CD4+ Th responses q CD8+ CTL responsesDelayed-type H
2、ypersensitivity (DTH)T cell-dependent immune reactions that cause normal tissues injuryNK cell mediated innate immunity, kill infected cell earlyq CD4+ Th1 responsesmicrobes residing within the phagosomes of phagocytes q CD8+ CTL responsesmicrobes residing in the cytoplasm of various cell types q CD
3、4+ Th2 responses helminthic parasitesq CD4+ Th17 responsesextracellular bacteria, fungi.Different types of microbes elicit distinct protective T cell responses Defects in CMI result in increased susceptibility to infection by viruses and intracellular bacteria Types of T cell-mediated immune respons
4、eMajor mediators of T cell-mediated immune responsesr Cytokinesr Membrane proteinsTNF family members: CD40L, TNF-, FasLTh1-Mediated Immune Responsesq The physiological role of Th1 cells phagocyte-mediated defense against infections, especially with intracellular microbes q Pathological roles of Th1 cellMany organ-specific autoimmune diseases and inflammatory reactionsare due to excessive activation of Th1 cells
