1、定义发病机制治疗-CRRT治疗内容提要定 义Systemic Inflammatory Response Syndrome (SIRS)At least 2 of the following 4 conditions: Oral temperature 38o or 20 breaths/min or PaCO2 of 90 beats/min WBC 12,000/uL or 10 percent bandsSepsis Severe sepsisSIRS that has a proven or suspected microbial etiology Sepsis with one or
2、 more signs of organ dysfunctionhypoperfusion, or hypotension such as metabolic acidosisacute alteration in mental status, oliguria, coagulation abnormalities or adult respiratory distress syndromeHypotension Systolic blood pressure 90 mmHg - or 40 mmHg less than patients baseline blood pressureSept
3、ic shock Sepsis with hypotension that is unresponsive to fluid resuscitation plus organ dysfunction or perfusion abnormalities as listed above for severe sepsisMultiple organ dysfunction syndrome (MODS)Dysfunction of more than one organ, requiring intervention to maintain homeostasis定 义Sepsis =Infec
4、tion+SIRSSevere sepsis=Sepsis + organ functionSeptic shock=Sepsis + hypotension损伤损伤 SIRS Sepsissevere sepsis (septic shock) MODS MOF感染的全过程infection院内感染发生率普通病房中病人 : 6-17%ICU病人：病人： 25-40%重症感染与 MODS重症感染常并发 MODS心、肺、肾、肝、脑等器官发生单一器官衰竭死亡率是 20随器官衰竭数量增加，死亡率逐渐上升，合并 4个器官衰竭患者死亡率达100 Deitch EA. Surg Clin N Am, 1999, 79: 1471-88Rangel-Frausto, M, et al. JAMA, 1995, 273:117-123 感染与重症感染对患者预后的影响MODS对患者预后的影响定义发病机制治疗-CRRT治疗内容提要
