1、 乳腺癌的辅助化疗与内分泌治疗郭书坤德州市第二人民医院乳腺科陈晓旭（ 1965.10.29 2007.5.13）红颜薄命 。Company Logo 阿桑 1975年 2月 2009年 4月Company Logo 乳腺癌是女性常见的恶性肿瘤Company Logo 乳腺癌的预防123减少致癌因素加强高危人群的预防重视肿瘤筛查Company Logo 乳腺癌的治疗Breast Cancer Treatment 手术治疗 Surgical Treatment 化疗 Chemotherapy 放疗 Radiation 内分泌治疗 Endocrine 靶向治疗 Target Treatment 其他
2、治疗 OthersCompany Logo Guideline Development ComparisonNCCN Guideline ASCO GuidelineSt Gallen ConsensusMethodology Evidence-based consensusEvidence-based (consensus)(Evidence-based) consensusCoverage Comprehensive Focused Early diseaseCOI disclosureYes Yes NoFrequency of updates Yearly As needed Ever
3、y 2 yearsAdvocate representativeYes Usually NoCompany Logo Company Logo 乳腺癌的外科治疗Surgical Treatment扩大根治术 Extensive Mastectomy乳癌根治术 Radical Mastectomy保乳手术 Breast Conservation前哨淋巴结活检 Sentinel Lymph Node Biopsy改良根治术 Modified MastectomyCompany Logo 乳腺癌辅助治疗的进展1960s 1970s 1980s 1990s 2000 2002 2003 Surgery
4、CMF1AnthracyclinesAC2, CAF3,FEC4Dose5,6CEF1207, 15FEC1008EC9Meta-analysis12Taxanes10,11,13DI14 Sequence Biologics1 Bonadonna 19762 B-15, B-23 1990, 20003 SECSG 19944 Coombes 19965 Bonadonna 1995 6 Wood 19947 MA-05 19988 FASG 20019 Belgium 2001 10 CALGB 200011 B-28 200012 EBCTCG 1998, 200013 TAC vs FAC14 CALGB 974115 MA.05 10 years!
