卵圆孔未闭封堵术：争论与发展May9,2009,AndrewD.Michaels,MD,MAS,FACC,FAHADirector,CardiacCatheterizationLaboratoryandInterventionalCardiologyUniversityofUtah,SaltLakeCity,Utah,胎儿循环,胎儿期，氧合血液由脐静脉经下腔静脉进入右房血流由下腔静脉经过Eustachian瓣流到卵圆窝.,出生后房间隔发育,宫内出生后,Hagen,Scholz.MayoClinProc1984;59:17-20.,人口的75人口的25%,PFO相关临床综合症,体位相关呼吸困难Platypneaorthodeoxia减压病/高原性肺水肿脑血管事件/TIA偏头痛,PlatypnoeaOrthodeoxia,罕见直立体位引起的呼吸困难，伴有低氧血症机制：右向左房间分流,Aigneretal.EurJCardiothorSurg2019;33:268.Medinaetal.Circulation2019;104:741.,PlatypneaOrthodeoxia,19
