甲状腺髓样癌的分子分型及治疗,解放军第一一七医院戚晓平,概况,HistologicsubtypesofthyroidcancerPapillary:approximately80%ofallthyroidmalignancies;FollicularandHrthle:approximately11%;Medullary:lessthan5%-8%;Anaplastic:lessthan2%.,Introduction,Medullarythyroidcancer(MTC)SporadicMTC:approximately75%;50%somaticRETmutations(p.M918T)-predictapoorprognosisHereditaryMTC:approximately25%;98%GermlineRETmutations,MEN2A(95%)andMEN2B(5%)Arisesfromtheneuralcrest-derived,calcitonin-secreting,parafollicularCcellsofthethyroidgland,
