InflammtoryBowelDisease（IBD)炎症性肠病,DepartmentofGastroenterologyJINANCENTRALHOSPITALChuChuanlian褚传莲,Defination定义,Idiopathicinflammatoryboweldisease多病因的、免疫介导的肠道慢性及复发性炎症Including:ulcerativecolitisUC溃疡性结肠炎CrhondiseaseCD克罗恩病未定型结肠炎,EtiologyandPathogenesis病因发病机制,一.Environmentalfactors环境因素欧洲发病率高，我国发病率逐渐上升diet,smokingetc二.Geneticsusceptibility遗传易感性IBD一级亲属发病率高易感位点位于第3.7.12.16号染色体上NOD2/CARD5基因突变与CD有关,EtiologyandPathogenesis病因发病机制,三.Infections感染因素:多种微生物参与bacterialandviral免疫缺陷小鼠模型临床：抗生素/肠道菌群,EtiologyandPatho
