OA是一种慢性肌肉骨骼疾病。在美国,OA是中老年人群慢性致残的主要原因,是50岁以上男性丧失工作能力的第2位原因(仅次于缺血性心脏病)美国每年用于骨关节炎治疗的花费高达890亿美元。,一、备受争议的氨基葡萄糖,硫酸氨基葡萄糖,BRUYEREO,PAVELKAK,ROVATILC,etal,Glucosaminesulfatereducesosteoarthritisprogressioninpostmenopausalwomenwithkneeosteoarthritis:evidencefrontwo3-yearstudiesJ.Menopause,2004,11(2):138-143.THIENM,PRASADNG,MAJORPW,Evaluationofglucosaminesulfatecomparedtoibuprofenforthetreatmentoftemporomandjointosteoarthritis:arandomizeddoubleblindcontrolled3monthclinicalJ.JRheumatol,2001,28(6):1347-