1、Liu BaochiShanghai Public Health Clinical Center affiliated to Fudan University,Treating patients with liver cirrhosis by BMT,Decompensated liver cirrhosis is difficult to cureliver cirrhosis with AIDS is more difficult to give effective treatmentStem cell treatment bring the hope for the patients o
2、f AIDS with decompensated liver cirrhosis.,BACKGROUND,7 AIDS patients with decompensated liver cirrhosis and portal ven hypertention , ascites, internal blooding were investigated.,Patients,Splenectomy were performed in 7 AIDS patients with liver cirrhosis to alleviate portal vein hypertention and a
3、void internal blooding.,Methods,During the surgical procedure, a catheter was placed in the superior mesenteric vein in preparation for bone marrow transfusion (BMT).,20mL bone marrow was aspirated by puncture of the iliac crest one week after surgery and transfused through the attached catheter int
4、o the portal vein.,Methods,Methods,One or two doses of BMT were performed on each patient at a one month interval.,Results,Except diminishment of ascites and recovery of serum albumin levels, total white blood cells and platelet count was also significantly improved. Unexpectedly, one month after BM
5、T, CD4+ T cell count in peripheral blood of all 7 patients began to increase significantly.,changes of CD4+ T lymph cell ( /ul),changes of CD8+ T lymph cell ( /ul),changes of albumin（g/L）,changes of Tbl（umol/L）,changes of WBC（109/L）,changes of Plate（109/L）,changes of Hb（g/L）,changes of PT(秒),liver c
6、irrhosis and highly enlarged spleen with huge amout of ascites before operation,four months after operation and BMT. Ascites disappeared and liver enlarged,It may change the standard of liver transplantation,Clinical significance of BMT,BMT for the AIDS patient with liver cirrhosis can promote liver function and immune reconstruction.,Conclusion,Thanks,
