先天性脊柱侧凸的诊断和治疗,先天性脊柱侧凸(Congenital scoliosis,CS),胚胎期脊柱发育异常 出生后即发病,1个椎体 形成障碍 2个椎体 部分/完全分节障碍,冠状位Cobb角10度,发病率0.5-1.0/1000,1. Shands AR, Eisberg HB. The incidence of scoliosis in the state of Delaware. A study of 50,000 minifilms of the chest made during a survey for tuberculosis. J Bone Joint Surg 1955;37A:1243.,占全部脊柱侧凸畸形的5.19%,流行病学,先天性脊柱侧凸病因,基因遗传因素,环境因素,?,CS及不同 临床表型,?,遗传背景,流行病学证据,家族聚集现象:脊椎肋骨发育不全(SCD) 脊椎胸骨发育不全(STD),Almenn :237个CS者中20.7% 2个家庭成员发生侧凸,1,Wynne Davies:337例先天性脊柱畸形绝大多数是散发