前药设计原理与应用实例张世平 制药工程 2111107010摘要 本文主要总结了前药设计的基本原理和在新药发现中的应用，并列举了几个相关的前药设计的应用实例。关键词：前药设计，应用实例，药理学和药动学The principle of pro-drug design and Applied CasesABSTRACT : the basic principles for pro-drug design and their applications in new drug discovery are summarized in the paper, and some relative cases about pro-drug design were listed.Key words : pro-drug design ; applied cases；pharmacology and Pharmacokinetics1 前药概述 前药是指在口服后经体内化学或酶代谢，能释放出有药效活性的代谢物或原药的化合物。它是将原药与一种载体经化学键连接，形成暂时的化学结合
