免疫治疗新进展 PD-1/PD-L1抑制剂 Nivolumab Pembrolizumab Atezolizumab MEDI4736等 CAR-T疗法 开启精准治疗时代Nivolumab对比多西他赛用于经治晚期 或转移性非小细胞肺癌鳞癌III期临床研 究:CheckMate 017 Brahmer et al. N Engl J Med, 2015;373(2):123-135Nivolumab improves OS compared to Docetaxel in Advanced Squamous-Cell NSCLC Nivolumab Docetaxel Hazard ratio ( 95% Cl ) P-value N 135 137 0.59(0.44,0.79 ) 0.00025 Number of deaths 86 113 Median OS , Month (95% Cl ) 9.2(7.3,13.3) 6(5.1,7.3) 1-year OS (95% Cl ) 42(34-50 ) 24(17-31 ) Brahmer et al. N Engl J Med