1、Pathogenesis and Treatment of Extranodal Natural Killer/T-Cell LymphomaSemin Hematol. 2014, 51:4251. Li Ye PATHOGENESIS OF NK/T-CELL LYMPHOMA1. Chromosomal abnormalities2. Genetic aberrations3. The Epstein-Barr virus(EBV)Chromosomal abnormalitiesDeletion of the long arm of chromosome 6Br J Haematol.
2、 1997;98:922-6.Chromosomal abnormalitiesBr J Haematol.1997;97:621-5.Genetic aberrationsFOXO3, PRDM1, TP53,CDKN2A,FAS,SHP1,TP73, and KITJ Clin Exp Hematopathol. 2005;45:51-70.PATHOLOGY OF NK/T-CELL NEOPLASMS1. diffuse proliferation of lymphoma cells with anangiocentric or angiodestructive growth patt
3、ern2. Infiltration of inflammatory cells and sometimes accompany necrotic changes 3. NK cell markers (CD2, cytoplasmic CD3 (cyCD3), CD7, and CD56 )4. Cytotoxic molecules such as TIA-1, granzyme B, and perforinDISEASE FEATURES OF NK/T-CELL LYMPHOMA1. origin for ENKL: the nose and paranasal areaskin,
4、gastrointestinal tract, et al.2. Stage I/II : Approximately half of the patients 3. Nasal and extranasal ENKLs in the same category of disease according to the current WHO classificationAnn Oncol. 2010;21:1032-40. Nasal ENKL more frequently presents as a localized disease, whereas extranasal ENKL is more frequently detected at an advanced stage.
