1、难治性感染性休克的ECMO治疗,宁波市第一医院 重症医学科 范 震,全身炎症反应综合症（SIRS）脓毒症： ( 可能或已有的) 感染引起的全身炎症反应。严重脓毒症： 脓毒症所致的组织低灌注或器官功能障碍。 脓毒性休克：脓毒症所致低血压，虽经液体复苏后仍无法逆转。,Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock: 2012,何为难治性脓毒症休克？,dened as evidence of organ hypoperfusion (extensi
2、ve skin mottling, progressive lactic acidosis, oliguria or altered mental status) ，despite adequate intravascular volume and the inability to maintain meanarterial pressure 65 mmHg despite infusion of very high-dosecatecholamines (norepinephrine 1 g/kg/min, dopamine 20g/kg/min or epinephrine 1 g/kg/
3、min with dobutamine 20g/kg/min),感染性休克流行病学,the mortality at 28 days in Patients with septic shock that was various from 49.2%-57.5%,The effect of early goal-directed therapy on treatment of critical patients with severe sepsis/septic shock: a multi-center, prospective, randomized, controlled study.Ea
4、rly Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock,需在 3 小时内完成的项目 1) 检测血乳酸水平 2) 应用抗生素前获取血液培养标本 3) 使用广谱抗生素 4) 低血压或血乳酸 4mmol/L 时，按 30 mL/kg 给予晶体液需在 6 小时内完成的项目 5) 应用血管升压药 ( 对早期液体复苏无效的低血压) 维持平均动脉压 (MAP) 65 mm Hg 6) 当经过容量复苏后仍持续性低血压 (即脓毒性休克) 或早期血乳酸 4 mmol/L (36 mg/dL) 时：测量中心静脉压 (C
5、VP)测量中心静脉血氧饱和度(Scvo2) 7) 如果早期血乳酸水平升高，应重复进行测量,严重脓毒症/脓毒症休克早期治疗,Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock: 2012,严重脓毒症/脓毒症休克早期治疗目标,最初6小时复苏目标： a) CVP：812 mm Hg。 b) MAP 65 mm Hg。 c) 尿量 0.5 mL/kg/hr。 d) 上腔静脉血氧饱和度 (ScvO2) 或混合静脉血氧饱和度 (SvO2) 分别为 70% 或
6、 65%。 e)动态监测乳酸水平。,Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock: 2012,最初 6 小时应达到的生理标准作为复苏目标，可使患者 28 天死亡率降低 15.9%。此治疗策略称为早期目标指导性输液治疗(49.2% VS 33.3%)。一项涉及 314 名严重脓毒症患者的8个多中心的研究显示在按照早期目标治疗后患者的 28 天死亡率降低了 17.7%(42.5% VS 24.8%),The effect of vasopres
7、sin on gastric perfusion in catecholamine-dependent patients in septic shock.Chest.2003;124:22562260,Patients with vasodilatory septic shock that remains unresponsive to aggressive fluid replacement and increases in catecholamine therapy continue to have an extremely high mortality rate (close to 10
8、0%).,24.8-33.3%的患者液体复苏差的感染性休克能否再进一步提高患者的治愈率？,ECMO的应用,各种急性心力衰竭的心脏支持 V-A ECMO各种急性呼吸衰竭的肺通气支持 V-V ECMOE-CPR脓毒症休克的患者在积极EGDT后循环呼吸仍未见明显改善的难治性感染性休克患者是否也可以行ECMO支持来改善氧供？,相关指南,相关指南,新生儿和小儿中的应用,636842例患者,总体死亡率39%,小儿严重脓毒症及脓毒症休克（PSS）49153例入选,ECMO治疗死亡率47.8%,RRT死亡率32.3%,ECMO+RRT死亡率58.%,4795接受了体外支持治疗（ECMO/RRT/ECMO+RR
9、T）,Extracorporeal therapies in pediatric severe sepsis: findings from the pediatric health-care information system Ruth et al. Critical Care (2015) 19:397,Extracorporeal therapies in pediatric severe sepsis: findings from the pediatric health-care information system Ruth et al. Critical Care (2015)
10、19:397,Pediatr Crit Care Med 2007 Vol. 8, No. 5,441例ECMO患者中有45例脓毒症休克患者行V-A ECMO支持，8例患者在插管前发生心跳骤停并行胸外按压。平均支持时间84小时（32-135h）。ECMO管路机械问题有17人发生，如：氧合器和泵头，管路血栓、插管移位。 47%患者脱机并最终出院。经胸插管灌注的ECMO支持者生存并出院率为73%，高于外周插管的44%。 对于首选股、颈内静脉-颈动脉插管，如流量过低或无法达到目标流量，改正中胸骨切开右心房插管-主动脉灌注。体重小于10kg患儿流量不小于150ml/kg/min，体重大于10kg患儿流
11、量2.4l/min/m2,DISCUSSIONThe benets include maintaining a substantially higher circuit blood ow Avoiding the potentially detrimental effects of left ventricular blood entering the aorta in patients with severe lung,Extracorporeal membrane oxygenation for refractory septic shock in children: One instit
12、utions experience Pediatr Crit Care Med 2007 Vol. 8, No. 5,Pediatr Crit Care Med 2011 Vol. 12,Patients: Twenty-three children with refractory septic shockwho received central ECMO primarily as circulatory support,RESULTSEight (35%) patients suffered cardiac arrest and required external cardiacmassag
13、e before ECMO. Eighteen (78%) patients survived to be decannulated off ECMO, and 17 (74%) children survived to hospital discharge. Higher pre-ECMO arterial lactate levels were associated with increased mortality (11.7 mmol/L in nonsurvivors vs. 6.0 mmol/L in survivors, p 20 g/kg/min with norepinephr
14、ine 1 g/kg/min),Nonsurvivors procalcitonin concentrations were higher than survivors levels (respectively, 164 ng/mL 78605 vs 41 ng/mL 11187; p = 0.008,Conclusions: VA-ECMO rescued more than 70% of the patients who developed refractory cardiovascular dysfunction during severe bacterial septic shock.
15、 Survivors reported good long-term quality of life. Venoarterial extracorporeal membrane oxygenation might represent a valuable therapeutic option for adults in severe septic shock with refractory cardiac and hemodynamic failure,小结2,对于各种积极治疗后仍持续恶化的难治性感染性休克，可尝试应用ECMO支持治疗难治性感染性休克患者中因心功能衰竭导致的休克应用ECMO治疗效果较好；因感染导致外周血管阻力下降的休克ECMO治疗效果欠佳,Thanks for your attion!,
