1、Apoptosis and Diseases,ConceptApoptotic process and changesKey molecules and Major pathwaysTechniques to detect apoptosisApoptosis-related diseasesInsufficient apoptosis in diseasesExcessive apoptosis in diseasesCoexistence of insufficient and excessive apoptosis in diseasesPrinciples of treatment,W
2、hat is Apoptosis ?,Apoptosis refers to the process in which the dying procedures that have been in advance deposited in cell are triggered by various causes from in vitro and in vivo, and eventually cause cell death. Programmed cell death（PCD）,Causes and Process of Apoptosis,Apoptotic changes -Morph
3、ological changes in apoptosis -Biochemical Changes in Apoptosis,Morphological changes in apoptosis,Cell membrane CytoplasmCell nucleus Apoptotic body Phagocytose,Normal Cell,Apoptotic Bodies,Budding,Changes of Cell membrane,Apoptosis and Necrosis,Morphological differences in apoptosis and necrosis,B
4、iochemical Changes in Apoptosis,Caspase activationEndonuclease activation,Most apoptotic proteolytic cleavage results from the action of caspasesCaspases are activated by proteolytic cleavageRemoval of prodomain and linker regionAssembly of the large and small subunits into an active enzyme complexTwo heterodimers interacting via the small subunits to form a tetramer with two catalytic sites Family members14,Caspases: (cysteine-containing aspartate-specific proteases),Caspase functions and structure,Classification of Caspases,半胱天冬酶的特征,
