1、国家重点实验室学术报告报告题目：The Gene Balance Hypothesis: How changes in chromosomal dosage affect gene expression, the phenotype and ultimately evolutionary processes报告人：James A. Birchler报告地点：理科楼 A201报告时间：5 月 31 日（周三）下午 2:00报告人简介：James A. Birchler 美国科学院院士， 博士毕业于 Indiana University，1985-1991年在 Harvard University
2、 任教，现为 University of Missourics 学监教授，世界著名的细胞遗传学家，主要从事玉米和果蝇遗传学研究：真核生物调控基因平衡、剂量补偿、基因沉默、着丝粒结构与功能的表观遗传学机理研究，以及人工染色体创建和植物杂种的理论和应用研究，是国际著名的该领域学术权威。在Cell、Science、Nature 、 Nature Genetics、PNAS 和 Plant cells 等国际著名学术杂志上发表过大量文章。从 1994 年开始就担任 Genetics（遗传学）期刊的副主编，同时担任 The Plant Cell、Maize Genetics Cooperation Ne
3、wsletter 等 9 个期刊的编委。迄今为止，James A. Birchler 博士荣获多项学术奖励和荣誉。发布人：叶文雪 联系方式：13770715820 Email：附：代表作：Birchler J, Sun L, Fernandez H, Donohue R, Xie W, and Sanyal A. Re-evaluation of the function of the male specific lethal complex in Drosophila. Journal of Genetics and Genomics, Article in Press.Xie W, Lia
4、ng C, and Birchler JA. Inhibition of RNA interference and modulation of transposable element expression by cell death in Drosophila. Genetics 2011;188(4):823-834.Koo DH, Han F, Birchler JA, and Jiang J. Distinct DNA methylation patterns associated with active and nactive centromeres of the maize B c
5、hromosome. Genome Research 2011, 21(6):908-914.Kato A, Lamb JC, Albert PS, Danilova T, Han F, Gao Z, Findley S, and Birchler JA. Chromosome painting for plant biotechnology. Methods in Molecular Biology 2011 (Clifton, N.J.);701:67-96.Yao H, Kato A, Mooney B, and Birchler JA. Phenotypic and gene expr
6、ession analyses of a ploidy series of maize inbred Oh43. Plant Molecular Biology 2011;75(3):237-251. Birchler JA, Gao Z, Sharma A, Presting GG, and Han F. Epigenetic aspects of centromere function in plants. Current Opinion in Plant Biology 2011;14(2):217-222.Gaeta RT, Danilova TV, Zhao C, Masonbrin
7、k RE, McCaw ME, and Birchler JA. Recovery of a telomere-truncated chromosome via a compensating translocation in maize. Genome 2011;54(3):184-195.Yu C, Danilova T, Zhang J, Birchler J and Peterson T. Constructing defined chromosome segmental duplications in maize. Cytogenetic and Genome Research 201
8、0;129(1-3):72-81.Veitia RA and Birchler JA. Dominance and gene dosage balance in health and disease: Why levels matter! Journal of Pathology 2010;220(2):174-185.Roark LM, Hui AY, Donnelly L, Birchler JA and Newton KJ. Recent and frequent insertions of chloroplast DNA into maize nuclear chromosomes.
9、Cytogenetic and Genome Research 2010;129(1-3):17-23.Riddle NC, Jiang H, An L, Doerge RW and Birchler JA. Gene expression analysis at the intersection of ploidy and hybridity in maize. Theoretical and Applied Genetics 2010;120(2):341-353.Masonbrink RE and Birchler JA. Sporophytic nondisjunction of th
10、e maize B chromosome at high copy numbers. Journal of Genetics and Genomics 2010;37(1):79-84.Masonbrink RE and Birchler JA. Sporophytic nondisjunction of the maize B chromosome at high copy numbers. Journal of Genetics and Genomics 2010;37(1):79-84.Birchler JA, Yao H, Chudalayandi S, Vaiman D and Ve
11、itia RA. Heterosis. Plant Cell 2010;22(7):2105-2112.Birchler JA and Veitia RA. The gene balance hypothesis: Implications for gene regulation, quantitative traits and evolution. New Phytologist 2010;186(1):54-62.Birchler JA and Pires JC. Cytogenetic and Genome Research: Preface. Cytogenetic and Genom
12、e Research 2010;129(1-3):5.Birchler JA and Pires JC. Advances in plant cytogenetics. Preface. Cytogenetic and Genome Research2010;129(1-3):5.Birchler JA, Krishnaswamy L, Gaeta RT, Masonbrink RE and Zhao C. Engineered minichromosomes in plants. Critical Reviews in Plant Sciences 2010;29(3):135-147.Bi
13、rchler JA, Gao Z and Han F. Pairing in plants: Import is important. Proceedings of the National Academy of Sciences of the United States of America 2010;106(47):19751-19752.Birchler JA. Reflections on studies of gene expression in aneuploids. Biochemical Journal2010;426(2):119-123.Albert PS, Gao Z,
14、Danilova TV and Birchler JA. Diversity of chromosomal karyotypes in maize and its relatives. Cytogenetic and Genome Research 2010;129(1-3):6-16.Wolfgruber TK, Sharma A, Schneider KL, Albert PS, Koo DH, Shi J, Gao Z, Han F, Lee H, Xu R, Allison J, Birchler JA, Jiang J, Dawe RK and Presting GG. Maize
15、centromere structure and evolution: Sequence analysis of centromeres 2 and 5 reveals dynamic loci shaped primarily by retrotransposons. PLoS Genetics 2009;5(11):art. no. e1000743.Sun X and Birchler JA. Studies on the short range spreading of the male specific lethal (MSL) complex on the X chromosome
16、 in Drosophila. Cytogenetic and Genome Research 2009;124(2):158-169.Sun X and Birchler JA. Interaction study of the male specific lethal (MSL) complex and trans-acting dosage effects in metafemales of drosophila melanogaster. Cytogenetic and Genome Research2009;124(3-4):298-311.Riddle NC, Jiang H, A
17、n L, Doerge RW and Birchler JA. Gene expression analysis at the intersection of ploidy and hybridity in maize. Theoretical and Applied Genetics 2009;120(2):341-353.Kavi H and Birchler J. Drosophila KDM2 is a H3K4me3 demethylase regulating nucleolar organization.BMC Research Notes 2009;2.Han F, Gao Z
18、 and Birchler JA. Reactivation of an inactive centromere reveals epigenetic and structural components for centromere specification in maize. Plant Cell 2009;21(7): 1929-1939.Birchler JA and Han F. Maize centromeres: structure, function, epigenetics. Annual Review of Genetics2009;43:287-303.Birchler
19、JA, Gao Z and Han F. Pairing in plants: Import is important. Proceedings of the National Academy of Sciences of the United States of America 2009;106(47):19751-19752.Birchler JA, Gao Z and Han F. A tale of two centromeres - Diversity of structure but conservation of function in plants and animals. F
20、unctional and Integrative Genomics 2009;9(1):7-13.Birchler JA. Dosage compensation for the birds. Heredity 2009;102(5):423-424.Veitia RA, Bottani S and Birchler JA. Cellular reactions to gene dosage imbalance: genomic, transcriptomic and proteomic effects. Trends in Genetics 2008.Vega JM, Yu W, Han
21、F, Kato A, Peters EM, Zhang ZJ and Birchler JA. Agrobacterium-mediated transformation of maize (Zea mays) with Cre-lox site specific recombination cassettes in BIBAC vectors.Plant Molecular Biology 2008;66(6):587-598.Riddle NC and Birchler JA. Comparative analysis of inbred and hybrid maize at the d
22、iploid and tetraploid levels. Theoretical and Applied Genetics 2008;116(4):563-576.Lough AN, Roark LM, Kato A, Ream TS, Lamb JC, Birchler JA and Newton KJ. Mitochondrial DNA transfer to the nucleus generates extensive insertion site variation in maize. Genetics 2008;178(1):47-55.Jin W, Lamb JC, Zhan
23、g W, Kolano B, Birchler JA and Jiang J. Histone modifications associated with both A and B chromosomes of maize. Chromosome Research 2008;16(8):1203-1214.Danilova TV and Birchler JA. Integrated cytogenetic map of mitotic metaphase chromosome 9 of maize: Resolution, sensitivity, and banding paint dev
24、elopment. Chromosoma 2008;117(4):345-356.Birchler JA, Yu W and Han F. Plant engineered minichromosomes and artificial chromosome platforms.Cytogenetic and Genome Research 2008;120(3-4):228-232.Birchler JA and Kavi HH. Molecular biology: Slicing and dicing for small RNAs. Science2008;320(5879):1023-1
25、024.Yu W, Lamb JC, Han F and Birchler JA. Cytological visualization of DNA transposons and their transposition pattern in somatic cells of maize. Genetics 2007;175(1):31-39.Yu W, Han F, Gao Z, Vega JM and Birchler JA. Construction and behavior of engineered minichromosomes in maize. Proceedings of t
26、he National Academy of Sciences of the United States of America 2007;104(21):8924-8929.Yu W, Han F and Birchler JA. Engineered minichromosomes in plants. Current Opinion in Biotechnology2007;18(5):425-431.Lamb JC, Yu W, Han F and Birchler JA. Plant chromosomes from end to end: telomeres, heterochrom
27、atin and centromeres. Current Opinion in Plant Biology 2007;10(2):116-122.Lamb JC, Riddle NC, Cheng YM, Theuri J and Birchler JA. Localization and transcription of a retrotransposon-derived element on the maize B chromosome. Chromosome Research 2007;15(3):383-398.Lamb JC, Meyer JM, Corcoran B, Kato
28、A, Han F and Birchler JA. Distinct chromosomal distributions of highly repetitive sequences in maize. Chromosome Research 2007;15(1):33-49.Lamb JC, Meyer JM and Birchler JA. A hemicentric inversion in the maize line knobless Tama flint created two sites of centromeric elements and moved the kinetoch
29、ore-forming region. Chromosoma2007;116(3):237-247.Lamb JC, Danilova T, Bauer MJ, Meyer UM, Holland JJ, Jensen MD and Birchler JA. Single-gene detection and karyotyping using small-target fluorescence in situ hybridization on maize somatic chromosomes. Genetics 2007;175(3):1047-1058.Han F, Lamb JC, Y
30、u W, Gao Z and Birchler JA. Centromere function and nondisjunction are independent components of the maize B chromosome accumulation mechanism. Plant Cell 2007;19(2):524-533.Han F, Gao Z, Yu W and Birchler JA. Minichromosome analysis of chromosome pairing, disjunction, and sister chromatid cohesion
31、in maize. Plant Cell 2007;19(12):3853-3863.Birchler JA, Yao H and Chudalayandi S. Biological consequences of dosage dependent gene regulatory systems. Biochimica et Biophysica Acta - Gene Structure and Expression 2007;1769(5-6):422-428.Birchler JA and Veitia RA. The gene balance hypothesis: From cla
32、ssical genetics to modern genomics.Plant Cell 2007;19(2):395-402.Yu W, Lamb JC, Han F and Birchler JA. Telomere-mediated chromosomal truncation in maize.Proceedings of the National Academy of Sciences of the United States of America 2006;103(46):17331-17336.Yu W, Han F, Kato A and Birchler JA. Chara
33、cterization of a maize isochromosome 8S-8S. Genome2006;49(6):700-706.Riddle NC, Kato A and Birchler JA. Genetic variation for the response to ploidy change in Zea mays L.Theoretical and Applied Genetics 2006;114(1):101-111.Lamb JC and Birchler JA. Retroelement genome painting: Cytological visualizat
34、ion of retroelement expansions in the genera zea and tripsacum. Genetics 2006;173(2):1007-1021.Kavi HH, Fernandez HR, Xie W and Birchler JA. Polycomb, pairing and PIWI - RNA silencing and nuclear interactions. Trends in Biochemical Sciences 2006;31(9):485-487.Kato A and Birchler JA. Induction of tet
35、raploid derivatives of maize inbred lines by nitrous oxide gas treatment. Journal of Heredity 2006;97(1):39-44.Kato A, Albert PS, Vega JM and Birchler JA. Sensitive fluorescence in situ hybridization signal detection in maize using directly labeled probes produced by high concentration DNA polymeras
36、e nick translation. Biotechnic and Histochemistry 2006;81(2-3):71-78.Han F, Lamb JC and Birchler JA. High frequency of centromere inactivation resulting in stable dicentric chromosomes of maize. Proceedings of the National Academy of Sciences of the United States of America 2006;103(9):3238-3243.Bir
37、chler JA, Yao H and Chudalayandi S. Unraveling the genetic basis of hybrid vigor. Proceedings of the National Academy of Sciences of the United States of America 2006;103(35):12957-12958.Birchler JA, Fernandez HR and Kavi HH. Commonalities in compensation. BioEssays 2006;28(6):565-568.Bhadra MP, Bha
38、dra U and Birchler JA. Misregulation of sex-lethal and disruption of male-specific lethal complex localization in drosophila species hybrids. Genetics 2006;174(3):1151-1159.Bauer MJ and Birchler JA. Organization of endoreduplicated chromosomes in the endosperm of Zea mays L. Chromosoma 2006;115(5):3
39、83-394.Theuri J, Phelps-Durr T, Mathews S and Birchler J. A comparative study of retrotransposons in the centromeric regions of A and B chromosomes of maize. Cytogenetic and Genome Research 2005;110(1-4):203-208.Ream TS, Strobel J, Roller B, Auger DL, Kato A, Halbrook C, Peters EM, Theuri J, Bauer M
40、J, Addae P, Dioh W, Staub JM, Gilbertson LA and Birchler JA. A test for ectopic exchange catalyzed by Cre recombinase in maize. Theoretical and Applied Genetics 2005;111(2):378-385.Matzke MA and Birchler JA. RNAi-mediated pathways in the nucleus. Nature Reviews Genetics2005;6(1):24-35.Lamb JC, Kato
41、A and Birchler JA. Sequences associated with A chromosome centromeres are present throughout the maize B chromosome. Chromosoma 2005;113(7):337-349.Kavi HH, Xie W, Fernandez HR and Birchler JA. Global analysis of siRNA-mediated transcriptional gene silencing. BioEssays 2005;27(12):1209-1212.Kavi HH,
42、 Fernandez HR, Xie W and Birchler JA. RNA silencing in Drosophila. FEBS Letters2005;579(26):5940-5949.Kato A, Zheng YZ, Auger DL, Phelps-Durr T, Bauer MJ, Lamb JC and Birchler JA. Minichromosomes derived from the B chromosome of maize. Cytogenetic and Genome Research 2005;109(1-3):156-165.Kato A, Ve
43、ga JM, Han F, Lamb JC and Birchler JA. Advances in plant chromosome identification and cytogenetic techniques. Current Opinion in Plant Biology 2005;8(2):148-154.Kato A, Lamb JC, Han F, Vega J and Birchler JA. Molecular analysis of maize chromosomes. Maydica2005;50(3-4):311-320.Jin W, Lamb JC, Vega
44、JM, Dawe RK, Birchler JA and Jiang J. Molecular and functional dissection of the maize B chromosome centromere. Plant Cell 2005;17(5):1412-1423.Fernandez HR, Kavi HH, Xie W and Birchler JA. Heterochromatin: On the ADAR radar? Current Biology2005;15(4):Della Vedova CB, Lorbiecke R, Kirsch H, Schulte
45、MB, Scheets K, Borchert LM, Scheffler BE, Wienand U, Cone KC and Birchler JA. The dominant inhibitory chalcone synthase allele C2-Idf (inhibitor diffuse) from Zea mays (L.) acts via an endogenous RNA silencing mechanism. Genetics 2005;170(4):1989-2002.Birchler JA, Riddle NC, Auger DL and Veitia RA.
46、Dosage balance in gene regulation: Biological implications. Trends in Genetics 2005;21(4):219-226.Bhadra MP, Bhadra U, Kundu J and Birchler JA. Gene expression analysis of the function of the male-specific lethal complex in drosophila. Genetics 2005;169(4):2061-2074.Auger DL, Peters EM and Birchler
47、JA. A genetic test of bioactive gibberellins as regulators of heterosis in maize. Journal of Heredity 2005;96(5):614-617.Auger DL, Gray AD, Ream TS, Kato A, Coe Jr EH and Birchler JA. Nonadditive gene expression in diploid and triploid hybrids of maize. Genetics 2005;169(1):389-397.Phelps-Durr TL an
48、d Birchler JA. An asymptotic determination of minimum centromere size for the maize B chromosome. Cytogenetic and Genome Research 2004;106(2-4):309-313.Pal-Bhadra M, Leibovitch BA, Gandhi SG, Rao M, Bhadra U, Birchler JA and Elgin SCR. Heterochromatic silencing and HP1 localization in drosophila are
49、 dependent on the RNAi machinery.Science 2004;303(5658):669-672.Lamb JC, Theuri J and Birchler JA. Whats in a centromere? Genome Biology 2004;5(9):Kato A, Lamb JC and Birchler JA. Chromosome painting using repetitive DNA sequences as probes for somatic chromosome identification in maize. Proceedings of the National Academy of Sciences of the United States of America 2004;101(37):13554-13559.Birchler JA and Newton KJ. Discovering the seeds of diversity in plant genomes. Genome Biology2004;5(5):Birchler JA, Kavi HH and Fernandez HR. Heterochromatin: RNA points the way. Cu
