1、Nanotechnology Based Drug DeliveryDr. Basavaraj K. Nanjwade M.Pharm., Ph.DAssociate ProfessorDepartment of PharmaceuticsJN Medical CollegeKLE UniversityBelgaum-59001020/03/2008 1Dept. of PharmaceuticsApplications of Nanotechnology20/03/2008 2Dept. of PharmaceuticsTargeted Drug Delivery20/03/2008 3De
2、pt. of PharmaceuticsNanoparticles for Drug Delivery Metal-based nanoparticles Lipid-based nanoparticles Polymer-based nanoparticles Biological nanoparticles20/03/2008 4Dept. of PharmaceuticsNanobiopharmaceuticals In biopharmaceuticals, in addition to the main technologies covered-liposomal, monoclon
3、al antibody-based, and polymer-based technologies host of newer technologies such as nanoparticles including various nanodimensional entities such as molecular imprinted polymers, metallofullerenes, prodrug delivery, oral, injectable and implantable, pulmonary, and transdermal and transmucosal deliv
4、ery have come up. 20/03/2008 5Dept. of PharmaceuticsDrug Delivery Technology Important to Pharma Industry Drug delivery formulations involve low cost research compared that for discovery of new molecule, Minimizing the drug use would significantly reduce the effective cost of drug which would give f
5、inancial relief to the patients, 20/03/2008 6Dept. of Pharmaceutics Delivery systems increase commercial opportunity by distinguishing a drug from competitive threats posed by “me too” drugs and Novel means of delivery particularly using nano-carriers, can allow branded drugs to be rescued from abys
6、s of generic competition (may be called “resurrection of drug”). Drug Delivery Technology Important to Pharma Industry20/03/2008 7Dept. of PharmaceuticsSOME SIGNIFICANT ACHIEVEMENTS OF NANODEVICES Development of one dose a day ciprofloxacin using nanotechnology Tumor targeted taxol delivery using na
7、noparticles in Phase 2 clinical trial stage Improved ophthalmic delivery formulation using smart hydrogel nanoparticles Oral insulin formulation using nanoparticles carriers. Liposomal based Amphotericin B formulation20/03/2008 8Dept. of PharmaceuticsCHALLENGES Prevention of drug from biological degradation Effective Targeting Patient Compliance Cost effectiveness Product life extension20/03/2008 9Dept. of PharmaceuticsPRIORITY AREAS Cancer Nanotechnology(i) Diagnosis using Quantum Dots(ii) Tumor Targeted Delivery(iii) Imaging(iv) Cancer Gene Therapy20/03/2008 10Dept. of Pharmaceutics
