1、肝样胃癌的临床病理特征、预后及研究展望AFP甲种胎儿球蛋白，甲型胎儿蛋白糖蛋白正常情况下，来自胚胎的 肝细胞 和卵黄囊。胎儿出生约两周后甲胎蛋白从血液中消失。正常人血清中甲胎蛋白的含量尚不到 20微克升。新生幼稚肝细胞（未分化完全）分泌 AFP量很大肝癌细胞（尚未分化的肝细胞 ）80-90%Hcc患者血清 AFP增高肝细胞癌 Hcc 90%肝外胆管细胞癌 Hcc10%原发性肝癌v甲胎蛋白是诊断原发性肝癌的一个 特异性 临床指标。 However!EXCEPTION!EXCEPTION!v 部分肝硬化病人会长期出现 AFP达到上千，但多年都没有肝癌的迹象。v 同时发现约 20%的晚期肝癌病人，直
2、至病故前， AFP仍不超过 10。v AFP与肿瘤大小有一定的相关性，即肿瘤越小，阳性率越低。vAFP也与病理类型相关，癌细胞分化 I级和 II级， AFP相对较低， 级时相对较高。 Some reports showed that AFP could also be produced by gastrointestinal tract organs, rectal carcinoma, gallbladder carcinoma, lung carcinoma, and bladder cancer.血清甲胎蛋白增高的原因 肝癌（ 阳性率 80-90%）随着病情恶化它在血清中的含量会急剧 增
3、加 急性肝炎慢性肝炎肝硬化孕妇 ;其他肿瘤的肝转移一过性升高随着病情的恢复，血清甲胎蛋白值会 下降 生殖细胞肿瘤阳性率 50%AFP阳性alpha-fetoprotein-producing gastric cancer (AFPGC)Hepatoid adenocarcinoma of the stomach (HAS)Concept:alpha-fetoprotein-producing gastric cancer (AFPPGC)At present time, it was generally accepted that the diagnostic criteria of AFP-
4、producing gastric cancer was positive staining of AFP in primary lesion regardless of serum AFP levelConcept of HAS 1. Hepatoid adenocarcinoma is a kind of extrahepatic tumor presentingmorphological areas identical to that of hepatocellular carcinomas.2. In addition to the histological similarity, it can also produceAFP-like hepatocellular carcinomas
