1、心力衰竭-糖尿病患者急性心肌梗死后无法回避的难题吴永健中国医学科学院 中国协和医科大学心血管病研究所 阜外心血管病医院糖尿病患者急性心肌梗死后心力衰竭The prevalence of heart failure is about 12% in people with Type 2 diabetes as compared to only 3.2% in non-diabetic subjectsAt 6 months, the incidence of HF was 24% (n=10) in the diabetics and 11% (n=30) in the non-diabetics
2、 (P=0.015)At 5 years, the rate of HF increased to 43% (n=18) in the diabetics and to 20% (n=57) in the non-diabetics (P=0.001). Heart failure in Type 2 diabetic patients following ACS Circulation 2000;102:1014-1019CHF event rate (%)05101520250 3 6 9 12 15 18 21 24DM+, CVD+DM-, CVD+DM+, CVD-DM-, CVD-
3、MonthsAcute Coronary SyndromeOR (95% CI) PAge, y 1.0513 (1.02841.0746) 0.0001Peak CK, U/L 1.0002 (1.00011.0002) 0.0004Six-month LV dilation, mL 1.0104 (1.00381.0170) 0.0021Diabetes 1.8026 (1.03743.1321) 0.0366Predictors of HF at Multivariate Cox Analysis (6 months)Circulation. 2004;110:1974-1979糖尿病急
4、性心肌梗死后 HF糖尿病急性心肌梗死后早期 HF的机制糖尿病急性心肌梗死后早期 HF的机制Diabetes and congestive HF independent of CADEndocrine Reviews 2004;25:543-567Small vesseldiseaseDiabeticcardiomyopathyLeft ventricular dysfunctionCardiac autonomicneuropathyCardiacinsulinresistance糖尿病急性心肌梗死后晚期 HF的机制Diabetes mellitus can accerate the prog
5、ression of post-infarction genetic regulatory expression in untreated Streptozotocin-induced Diabetic Rat Model-Genetic findings in the remote zone of LV free wall post acute myocardial infarctionGuang-Yuan Song1, Yong-Jian Wu1*, Yue-Jin Yang1, Jian-Jun Li1, Rui Li2, Ru-Tai Hui3, Han-Jun Pei1, Zhen-
6、Yan Zhao1From the 1Center of Coronary Heart Disease, 3Center of Hypertension, Cardiovascular Institute Center of Coronary Heart Disease, Department of Cardiology, Cardiovascular Institute & Fu-Wai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 167 BeiLiShi Rd, Beijing, 100037, P.R. China.E-mail:
