1、第三章 药物化学n Medicinal Chemistryn Pharmaceutical Chemistryn Pharmaco chemistryn 药品（ Drug,Medicine） ： 指用于预防、治疗、诊断人的疾病，有目的地调节人的生理机能并规定有适应症或功能主治、用法、用量的物质，包括中药材、中药饮片、中成药、化学原料药及其制剂、抗生素、生化药品、放射性药品、血清疫苗、血液制品和诊断药品等。 No medicine has only benefits or drawbacks Morphine Excellent analgesic Addictive, tolerance Re
2、spiratory depression Barbiturates Depressants, sedatives, anesthetics Surgery Overdoses fatal “Good” vs. “Bad” Drugs Diamorphine One of the best painkillers (“hero”) 1898: on market 1903: withdrawn (addictive properties) Today: still usedHeroinEveryday drugsn Still produce a response; many are addic
3、tiven Caffeinen Sugarn Nicotinen Alcoholn Food additivesn Vitaminsn Herbs n Basil: 50 potential carcinogensn Cultural aspectsMedicinal Chemistry Under what conditions are drugs “good,” and what do they do to the body? Curare/Tubocurarine“Good” vs. “Bad” Drugsn Depends on:n Dosagen Almost anything in excess will be toxicn Chronic exposuren Measure of safety of drug = therapeutic index
